| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Bile acid dysmetabolism in Bangladeshi infants associated with poor linear growth, enteric inflammation, and small intestine bacterial overgrowth
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Farah Hasan, Phillip B Hylemon, Rashidul Haque, William A Petri, Abu Syed Golam Faruque, Beth D Kirkpatrick, Madud Alam, Tahsin Ferdous, Talat Shama, Brett Moreau, Girija Ramakrishnan, Huiping Zhou, Alden Chesney, Felix Medrano Garcia, Ekaterina Smirnova, Preethi Prem, Yingsi Huang, Rashmi Bojja, Anubhav Thapaliya and Jeffrey R Donowitz |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Children’s Hospital Foundation at VCU |
1K23HD097282 |
| National Institutes of Health |
5R01AI043596 |
| Bill and Melinda Gates Foundation |
OPP1017093 |
| VA Merit Award |
5I01BX005730 |
| VA ShEEP Grants |
1 IS1 BX004777-01 |
| National Institutes of Health Grant |
2R56DK115377-05A1 |
| PIDS Summer Research Scholars Award |
|
| VCU SOM Dean’s Summer Research Fellowship |
|
| Research Career Scientist Award from the Department of Veterans Affairs |
IK6BX004477 |
|
| Corresponding Author |
Farah Hasan, MD, Virginia Commonwealth University, School of Medicine, 1201 E Marshall St, Richmond, VA 23298, United States. hasanf2@vcu.edu |
| Key Words |
Bile acid metabolism; Malnutrition; Environmental enteric dysfunction; Small intestinal bacterial overgrowth; Bangladesh |
| Core Tip |
This study identifies a previously unrecognized defect in bile acid conjugation among Bangladeshi infants with environmental enteric dysfunction, linking altered bile acid metabolism to poor growth and intestinal inflammation. Elevated unconjugated primary bile acids were strongly associated with anthropometry. Further, the findings highlight a possible age-related delay in maturation of bile acid conjugation pathways in impoverished children. This study may provide the initial insights for exploring novel therapeutic targets through bile acid pathways for treating malnourished children worldwide. |
| Publish Date |
2025-11-20 07:56 |
| Citation |
<p>Hasan F, Hylemon PB, Haque R, Petri WA, Faruque ASG, Kirkpatrick BD, Alam M, Ferdous T, Shama T, Moreau B, Ramakrishnan G, Zhou H, Chesney A, Medrano Garcia F, Smirnova E, Prem P, Huang Y, Bojja R, Thapaliya A, Donowitz JR. Bile acid dysmetabolism in Bangladeshi infants associated with poor linear growth, enteric inflammation, and small intestine bacterial overgrowth. <i>World J Gastroenterol</i> 2025; 31(43): 111609</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i43/111609.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i43.111609 |
