| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Si, Bo Tian, Rui Zhang, Ming-Da Xuan, Kun-Yi Liu, Jiao Jiao, Shuang-Shuang Han, Hong-Fei Li, Yan-Hong Hu, Hong-Yan Zhao, Wen-Jing He, Jia Wang, Ting Liu and Wei-Fang Yu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Hebei Natural Science Foundation |
No. H2025206524 |
| Hebei Natural Science Foundation |
No. H2022206292 |
| Hebei Natural Science Foundation |
No. H2024206140 |
| Hebei Provincial Government-funded Provincial Medical Excellent Talent Project |
No. ZF2023025 |
| Hebei Provincial Government-funded Provincial Medical Excellent Talent Project |
No. ZF2024134 |
| Hebei Provincial Government-funded Provincial Medical Excellent Talent Project |
No. LS202008 |
| Key RD Program of Hebei Province |
No. 223777103D |
| Key RD Program of Hebei Province |
No. 223777113D |
| Prevention and Treatment of Geriatric Diseases by Hebei Provincial Department of Finance |
No. LNB202202 |
| Prevention and Treatment of Geriatric Diseases by Hebei Provincial Department of Finance |
No. LNB201909 |
| Spark Scientific Research Project of the First Hospital of Hebei Medical University |
No. XH202504 |
| Spark Scientific Research Project of the First Hospital of Hebei Medical University |
No. XH202312 |
| Spark Scientific Research Project of the First Hospital of Hebei Medical University |
No. XH201805 |
| Hebei Province Medical Applicable Technology Tracking Project |
No. G2019035 |
|
| Corresponding Author |
Wei-Fang Yu, Gastrointestinal Disease Diagnosis and Treatment Center, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang 050000, Hebei Province, China. yuweifang@hebmu.edu.cn |
| Key Words |
Gastric cancer; N6-methyladenosine; IGF2BP3; FBXO32; Cyclic guanosine monophosphate-protein kinase G |
| Core Tip |
IGF2BP3 is highly expressed in gastric cancer and is closely associated with poor patient prognosis. IGF2BP3 promotes gastric cancer growth and progression both in vivo and in vitro. Mechanistically, IGF2BP3 recognizes and binds to N6-methyladenosine-modified site on FBXO32 messenger RNA, thereby upregulating FBXO32 protein expression. This activates the downstream cyclic guanosine monophosphate-protein kinase G (cGMP-PKG) signaling pathway, thereby regulating multiple biological functions of gastric cancer cells and promoting tumor progression. We propose that targeting of the IGF2BP3/FBXO32/cGMP-PKG axis could represent a promising therapeutic modality for gastric cancer. |
| Publish Date |
2025-12-10 07:48 |
| Citation |
Si Y, Tian B, Zhang R, Xuan MD, Liu KY, Jiao J, Han SS, Li HF, Hu YH, Zhao HY, He WJ, Wang J, Liu T, Yu WF. IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression. World J Gastroenterol 2025; 31(46): 111631 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i46/111631.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i46.111631 |
