| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue-Shan Sun, Xiao-Qin Bai, Kai-Di Sun, Jiao Li, Lei Liu, Yuan-Yuan Chen, Zhao-Yu Zeng, Qiong Wang and Yuan-Biao Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81270465 |
| the Sichuan Science and Technology Program |
2024NSFSC0631, 2023JDRC0088, MZGC20240097 |
| the Basic Research Cultivation Support Program of Fundamental Research Funds for the Central Universities |
2682023ZTPY071 |
| the Baiqiuen Public Welfare Foundation Program |
BCF-LX-XH-20221014-12 |
| the Third People’s Hospital of Chengdu Clinical Research Program |
CSY-YN-01-2023-012 and CSY-YN-03-2024-013 |
| the Yibin Science and Technology Program |
2021ZYY009 |
| the Chengdu Medical Research Project Foundation |
2022284 |
|
| Corresponding Author |
Yuan-Biao Guo, PhD, Medical Research Center, The Third People's Hospital of Chengdu, No. 82 Qinglong Street, Qingyang District, Chengdu 610031, Sichuan Province, China. guoyuanbiao@swjtu.edu.cn |
| Key Words |
Thymosin β4; Intestinal barrier; Mast cell; Janus kinase 1/signal transducer and activation of transcription 3; Irritable bowel syndrome |
| Core Tip |
Thymosin β4 (Tβ4) is identified as a prevalent component in the intestinal mucus of irritable bowel syndrome patients that is capable of independently causing intestinal barrier disruption, even without the involvement of mast cells, when triggered by either corticotropin-releasing hormone (CRH) or stress. In addition, mast cells are the source of the Tβ4 required for intestinal barrier damage, and its release is contingent on CRH/CRHR1 but not on degranulation. Mechanistically, the impact of Tβ4 on both the physical and immune barriers is mediated through the inhibition of Janus kinase 1/signal transducer and activation of transcription 3 signaling. These findings position Tβ4 as a promising diagnostic biomarker and therapeutic target for irritable bowel syndrome. |
| Publish Date |
2025-11-13 06:51 |
| Citation |
<p>Sun YS, Bai XQ, Sun KD, Li J, Liu L, Chen YY, Zeng ZY, Wang Q, Guo YB. Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier via IL22RA1/JAK1/STAT3 signaling in irritable bowel syndrome. <i>World J Gastroenterol</i> 2025; 31(42): 111706</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i42/111706.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i42.111706 |
