BPG is committed to discovery and dissemination of knowledge
Featured Articles
9/25/2025 3:42:35 AM | Browse: 230 | Download: 52
 |
Received |
|
2025-07-16 13:26 |
|
Peer-Review Started |
|
2025-07-16 13:26 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-08-08 09:36 |
|
Revised |
|
2025-08-21 16:12 |
|
Second Decision |
|
2025-09-10 02:46 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-09-10 06:46 |
|
Articles in Press |
|
2025-09-10 06:46 |
|
Publication Fee Transferred |
|
2025-08-25 10:02 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-09-22 02:09 |
|
Publish the Manuscript Online |
|
2025-09-25 03:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Bo Guo, Lu-Yao Wang, Xi-Ju Guo, Jing Yang, Wen Li, Fa-Yao Shen, Yu-Ting Li, Jin-Hui Yang and Wen-Lin Tai |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82160106 |
|
| Corresponding Author |
Jin-Hui Yang, Chief Physician, Full Professor, Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, No. 374 Dianmian Avenue, Wuhua District, Kunming 650101, Yunnan Province, China. yangjinhui@kmmu.edu.cn |
| Key Words |
Liver failure; Artificial liver support system; Plasma exchange; Alpha-fetoprotein; Liver function; Survival rate; Prognostic prediction |
| Core Tip |
This study establishes that baseline alpha-fetoprotein (AFP) stratification (< 100 ng/mL, 100-200 ng/mL, > 200 ng/mL) in liver failure patients receiving plasma exchange-based artificial liver support systems predicts regenerative capacity and clinical outcomes. High-AFP patients (> 200 ng/mL) baseline AFP levels demonstrated improved liver function recovery, fewer complications, and required fewer treatment sessions compared to those with lower levels. Critically, three-month survival was dose-dependent, with baseline AFP > 200 ng/mL providing excellent prognostic discrimination. Serial AFP monitoring enables precision artificial liver support systems therapy by identifying patients with high endogenous regenerative potential. |
| Publish Date |
2025-09-25 03:33 |
| Citation |
<p>Guo WB, Wang LY, Guo XJ, Yang J, Li W, Shen FY, Li YT, Yang JH, Tai WL. Prognostic value of serum alpha-fetoprotein kinetics in liver failure on artificial liver support. <i>World J Gastroenterol</i> 2025; 31(37): 111914</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i37/111914.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i37.111914 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
