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12/15/2025 9:58:44 AM | Browse: 221 | Download: 283
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2025-07-23 07:47 |
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2025-11-03 09:10 |
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2025-12-15 09:46 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Feng Ding, Xin Dang and Shan Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Project of the Affiliated Hospital of North Sichuan Medical College |
No. 2023ZD008 |
| Project of the Doctoral Initiation Fund |
No. 2023GC002 |
| Scientific Research and Development Program Project |
No. 2024PTZK008 |
| Sichuan Province Clinical Key Specialty Construction Project |
No. 2023GZZKP002 |
| Science and Technology Project of Nanchong |
No. 22SXQT0364 |
| Research Development Plan Project of Affiliated Hospital of North Sichuan Medical College |
No. 2024MPZK003. |
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| Corresponding Author |
Shan Lin, MD, Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, No. 1 South Maoyuan Road, Nanchong 637000, Sichuan Province, China. dr.shanlin@foxmail.com |
| Key Words |
Diabetic neuropathy; Proteome; Transcriptome; Therapeutic targets; Mendelian randomization; Multi-omics |
| Core Tip |
This integrated multi-omics study identified nine diabetic neuropathy (DN)-associated plasma proteins, validated across independent datasets. BTN3A1 and MICB emerged as top-tier therapeutic targets, robustly confirmed via Mendelian randomization (MR), summary-data-based MR, and colocalization analyses. Functional enrichment links these proteins to inflammation and neuronal injury. Crucially, cyclosporine A was predicted as a potential repurposed drug candidate targeting MICB. Furthermore, two-step network MR revealed MICB mediates DN risk specifically through human leukocyte antigen-DR++ monocyte abundance, providing a novel mechanistic immune pathway. This work unveils BTN3A1 and MICB as promising targets and elucidates MICB’s immune-mediated role in DN pathogenesis. |
| Publish Date |
2025-12-15 09:46 |
| Citation |
Ding XF, Dang X, Lin S. Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. World J Diabetes 2025; 16(12): 111963 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i12/111963.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i12.111963 |
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