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12/5/2025 11:30:28 AM | Browse: 34 | Download: 65
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Received |
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2025-07-15 11:20 |
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Peer-Review Started |
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2025-07-15 11:20 |
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First Decision by Editorial Office Director |
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2025-07-28 08:28 |
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Return for Revision |
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2025-07-28 08:28 |
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Revised |
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2025-08-13 07:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-13 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 07:10 |
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Articles in Press |
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2025-11-13 07:10 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-19 09:34 |
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Publish the Manuscript Online |
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2025-12-05 11:28 |
| ISSN |
2150-5349 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rajiv Mehta, Archi Patel, Bhavin Vyas, Bhargavi Desai, Dhvani Adhvaryu, Prakash Sojitra and Simple Bhuptani |
| Funding Agency and Grant Number |
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| Corresponding Author |
Rajiv Mehta, Department of Gastroenterology, SIDS Hospital and Research Centre, Surat Institute of Digestive Sciences, Khatodra-bamroli road, near Shell Petrol pump, Surat 395002, Gujarat, India. rmgastro@yahoo.com |
| Key Words |
Pirfenidone; Simvastatin; Chronic pancreatitis; L-arginine; Oxidative stress |
| Core Tip |
Combination therapy with pirfenidone and simvastatin significantly attenuated inflammation, fibrosis, and oxidative stress in an L-arginine-induced mouse model of chronic pancreatitis. The synergistic action led to reduced tumor necrosis factor-alpha, transforming growth factor-beta 1, and lipid peroxidation levels, along with a preservation of pancreatic tissue architecture. The combination therapy also enhanced antioxidant defense as evidenced by increased glutathione peroxidase 1 activity, indicating mitigation of oxidative damage. These findings highlighted a promising strategy targeting multiple pathological pathways, namely inflammatory, fibrotic, and oxidative stress mechanisms, and supported further evaluation of this combination in translational and clinical studies for chronic pancreatitis. |
| Publish Date |
2025-12-05 11:28 |
| Citation |
Mehta R, Patel A, Vyas B, Desai B, Adhvaryu D, Sojitra P, Bhuptani S. L-arginine-induced chronic pancreatitis in mice: Evaluating effects of pirfenidone and simvastatin. World J Gastrointest Pharmacol Ther 2025; 16(4): 111977 |
| URL |
https://www.wjgnet.com/2150-5349/full/v16/i4/111977.htm |
| DOI |
https://dx.doi.org/10.4292/wjgpt.v16.i4.111977 |
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