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10/25/2025 1:09:40 PM | Browse: 108 | Download: 159
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Received |
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2025-07-15 09:09 |
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Peer-Review Started |
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2025-07-16 00:10 |
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To Make the First Decision |
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Return for Revision |
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2025-08-19 09:24 |
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Revised |
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2025-08-28 20:36 |
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Second Decision |
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2025-10-08 09:57 |
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Accepted by Journal Editor-in-Chief |
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2025-10-08 22:38 |
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Accepted by Executive Editor-in-Chief |
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2025-10-13 09:45 |
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Articles in Press |
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2025-10-13 09:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-10-14 10:45 |
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Typeset the Manuscript |
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2025-10-17 08:32 |
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Publish the Manuscript Online |
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2025-10-25 01:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell & Tissue Engineering |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Living bio-drug therapies using mesenchymal stem cells and exosomes for mechanically ventilated patients with acute respiratory distress syndrome: A systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Moaz Safwan, Mariam Safwan Bourgleh, Abdulsalam Al-Ruqi, Omran Shrebaty, Faisal Almujaydil, Basel AlOthaim, Nasser AlRashidi and Khawaja Husnain Haider |
| Funding Agency and Grant Number |
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| Corresponding Author |
Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, AlQaseem, Saudi Arabia. khhaider@gmail.com |
| Key Words |
Acute respiratory distress syndrome; COVID-19; Exosomes; Living bio-drugs; Mesenchymal stem cells; Meta-analysis; Network stem cells |
| Core Tip |
Mesenchymal stem cells, as a living bio-drug, are being considered a potential treatment for coronavirus disease 2019-induced acute respiratory distress syndrome due to their immunomodulatory and reparative properties. Our systematic review and meta-analysis, involving 16 randomized controlled trials (n = 1027 acute respiratory distress syndrome patients), is the first study to directly compare the therapeutic benefits of mesenchymal stem cell-based and their derivative exosome-based therapeutic approaches. Although we did not find significant differences in their safety profiles and efficacy, the exosome-based treatment ranked higher in terms of therapeutic benefits in a network meta-analysis, offering practical and logistical advantages. |
| Publish Date |
2025-10-25 01:11 |
| Citation |
<p>Safwan M, Bourgleh MS, Al-Ruqi A, Shrebaty O, Almujaydil F, AlOthaim B, AlRashidi N, Haider KH. Living bio-drug therapies using mesenchymal stem cells and exosomes for mechanically ventilated patients with acute respiratory distress syndrome: A systematic review and meta-analysis. <i>World J Stem Cells</i> 2025; 17(10): 111978</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i10/111978.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i10.111978 |
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