| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Observational Study |
| Article Title |
Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Dimitra Bacharaki, Elias Kyriakou, Aggeliki Sardeli, Petros Nikolopoulos, George Triantaphyllis, Athina Drakou, Fotis Makris, Eleni Spanou, Eleni Triantou, Emmanouel Haviaras, Alexandra Fatourou, Aristarchos Poulis, Argyrios Tsantes, John Kyriazis and Sophia Lionaki |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Dimitra Bacharaki, MD, PhD, Clinical and Interventional Nephrology Unit, Attikon University General Hospital, Rimini 1, Chaidari 12462, Attikí, Greece. bacharaki@gmail.com |
| Key Words |
Apixaban; Chronic hemodialysis; Non valvular atrial fibrillation; Bleeding; Prediction; Rotational thromboelastometry; Platelet function assay |
| Core Tip |
The clinical dilemma of anticoagulation choice in hemodialysis patients with non-valvular atrial fibrillation is still unresolved. Apixaban use yields so far conflicting results. We conducted a pilot study in hemodialysis patients with non-valvular atrial fibrillation on apixaban, where we measured once on a non-dialysis day drug levels and rotational thromboelastometry before and after the morning pill under the dosing regimen used in clinical practice. Then we registered bleeding and thrombotic events. We found that CT by rotational thromboelastometry EXTEM after the morning pill was associated with bleeding events and thus could potentially be used as a prediction tool. |
| Publish Date |
2025-12-24 09:56 |
| Citation |
Bacharaki D, Kyriakou E, Sardeli A, Nikolopoulos P, Triantaphyllis G, Drakou A, Makris F, Spanou E, Triantou E, Haviaras E, Fatourou A, Poulis A, Tsantes A, Kyriazis J, Lionaki S. Bleeding prediction by rotational thromboelastometry in chronic hemodialysis patients with non-valvular atrial fibrillation on apixaban. World J Cardiol 2025; 17(12): 112046 |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i12/112046.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i12.112046 |
