| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Proteomics-based investigation of the protective effect and mechanism of Agari-5 in rats with myocardial infarction
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Bao Zhao, Zhi-Hong Bao, Ya Tu, Xia Qiu, Yin-Lan Bao, Min Su, Hai-Jun Qi and Quan Wan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| HingganLeague Science and Technology Programme Project |
No. MBJH2023022 |
|
| Corresponding Author |
Quan Wan, Associate Chief Physician, PhD, Department of Cardiovascular Medicine, Affiliated Hospital of Inner Mongolia Minzu University, No. 1742 East Section of Huolinghe Street, TongLiao 028000, Inner Mongolia Autonomous Region, China. wanquan120@126.com |
| Key Words |
Myocardial infarction; Agari-5; Proteomics; Protective effect; Mechanism |
| Core Tip |
These results showed that, in myocardial infarction (MI) rats treated with Agari-5, the expression levels of these proteins were comparable to those in the control group, suggesting that SDF2, PDK1, SMAD4, and PSAT1 may be important targets influenced by Agari-5. This study applied a logical approach of “disease-drug-target” to preliminarily verify the efficacy of Agari-5 in treating MI in rats. Moreover, through proteomic analysis, the research delved deeper into the protective mechanisms of Mongolian traditional medicine formulas, finding that these traditional formulas may protect MI rats through the regulation of multiple protein targets and molecular mechanisms, such as multi-component interactions and synergistic effects, providing a new direction for research on national medicines and offering a reference for clinical treatments of cardiovascular diseases. |
| Publish Date |
2025-12-24 09:56 |
| Citation |
Zhao YB, Bao ZH, Tu Y, Qiu X, Bao YL, Su M, Qi HJ, Wan Q. Proteomics-based investigation of the protective effect and mechanism of Agari-5 in rats with myocardial infarction. World J Cardiol 2025; 17(12): 112062 |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i12/112062.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i12.112062 |
