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10/24/2025 6:21:31 AM | Browse: 20 | Download: 62
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Received |
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2025-07-18 02:54 |
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Peer-Review Started |
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2025-07-18 02:55 |
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To Make the First Decision |
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Return for Revision |
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2025-07-23 08:42 |
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Revised |
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2025-07-31 01:31 |
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Second Decision |
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2025-09-01 02:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-02 02:26 |
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Articles in Press |
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2025-09-02 02:26 |
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Publication Fee Transferred |
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2025-08-05 08:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-17 01:52 |
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Publish the Manuscript Online |
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2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Overcoming chemoresistance in non-small cell lung cancer: Insights into the influence of inflammatory factors on treatment response
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Dai, Ya-Yun Liu, Nian Cao, Xiu-Wen Tian, Juan Feng, Zhen-Zhen Hu and Jian-Qiang Xu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jian-Qiang Xu, MD, Department of Pulmonary and Critical Care Medicine, the Third Clinical Medical College of the Three Gorges University, Gezhouba Central Hospital of Sinopharm, the Third Clinical Medical College of the Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang 443002, China. xjqdll930@163.com |
| Key Words |
Non-small cell lung cancer; Tumor microenvironment; Cisplatin; Chemotherapy sensitivity; Inflammatory cytokines |
| Core Tip |
This study explores the association between inflammatory cytokines and cisplatin (DDP) resistance in non-small cell lung cancer (NSCLC). Elevated levels of interleukin (IL)-6, IL-8, and tumor necrosis factor-α were detected in DDP-resistant tissues and cells. Notably, inhibition of IL-6 using the receptor antagonist tocilizumab restored DDP sensitivity by reducing cell viability, migration, and invasion, while enhancing apoptosis. These findings underscore IL-6 as a promising therapeutic target to overcome DDP resistance in NSCLC. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
<p>Dai Y, Liu YY, Cao N, Tian XW, Feng J, Hu ZZ, Xu JQ. Overcoming chemoresistance in non-small cell lung cancer: Insights into the influence of inflammatory factors on treatment response. <i>World J Clin Oncol</i> 2025; 16(10): 112097</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/112097.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.112097 |
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