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9/18/2025 10:08:33 AM | Browse: 265 | Download: 63
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Received |
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2025-07-21 01:13 |
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Peer-Review Started |
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2025-07-21 01:13 |
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To Make the First Decision |
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Return for Revision |
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2025-08-15 09:26 |
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Revised |
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2025-08-24 18:35 |
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Second Decision |
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2025-09-03 02:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-03 06:28 |
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Articles in Press |
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2025-09-03 06:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-08 07:40 |
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Publish the Manuscript Online |
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2025-09-18 09:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Expanding the genetic landscape of colorectal polyposis: Progress and challenges
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Arkadeep Dhali, Rick Maity and Jyotirmoy Biswas |
| Funding Agency and Grant Number |
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| Corresponding Author |
Arkadeep Dhali, MD, Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Northern General Hospital, Herries Road, Sheffield S5 7AU, United Kingdom. arkadipdhali@gmail.com |
| Key Words |
Colorectal tumor; Whole exome sequencing; Genetic heterogeneity; Wnt/beta-catenin pathway; Genetic variant |
| Core Tip |
This study applies whole-exome sequencing to a Brazilian cohort with unexplained colorectal polyposis, identifying candidate germline variants in 44.4% of patients. The findings highlight the involvement of genes in the Wnt/β-catenin signaling pathway, suggesting biological relevance to colorectal cancer development. Notably, the study addresses the potential for oligogenic inheritance, challenging the traditional monogenic framework for hereditary cancer syndromes. The work emphasizes the need for functional validation, population-specific variant databases, and careful clinical interpretation to translate genetic discoveries into meaningful patient care. |
| Publish Date |
2025-09-18 09:55 |
| Citation |
<p>Dhali A, Maity R, Biswas J. Expanding the genetic landscape of colorectal polyposis: Progress and challenges. <i>World J Gastroenterol</i> 2025; 31(35): 112220</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i35/112220.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i35.112220 |
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