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12/11/2025 8:26:15 AM | Browse: 22 | Download: 66
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Received |
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2025-07-25 00:53 |
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Peer-Review Started |
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2025-07-25 01:06 |
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First Decision by Editorial Office Director |
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2025-08-22 08:29 |
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Return for Revision |
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2025-08-22 09:21 |
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Revised |
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2025-08-29 09:22 |
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Publication Fee Transferred |
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2025-09-10 05:59 |
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Second Decision by Editor |
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2025-10-29 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-29 06:22 |
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Articles in Press |
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2025-10-29 06:22 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 00:31 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Involvement of bile acids in cholangiocarcinoma progression via the Hippo-yes-associated protein signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun Hu, Gan Zhang, Shuo Yang, Xian-Feng Shen, Meng Zhou, Lin-Sheng Huang and Hao-Ming Lan |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hao-Ming Lan, Department of Hepatopancreatobiliary Surgery, Taihe Hospital, Hubei University of Medicine, No. 32 Renmin South Road, Maojian District, Shiyan 442000, Hubei Province, China. bagwell1986@163.com |
| Key Words |
Bile acids; Cholangiocarcinoma; Hippo-yes-associated protein signaling; Tumor progression mechanisms; Molecular interventions |
| Core Tip |
Cholangiocarcinoma is a highly aggressive malignancy with limited therapeutic options. This study demonstrates that glycochenodeoxycholic acid promotes tumor growth and aggressiveness by activating the Hippo-yes-associated protein (YAP) signaling pathway, whereas deoxycholic acid suppresses tumor progression by enhancing YAP phosphorylation and inducing apoptosis. The use of YAP modulators further confirmed the opposing roles of these bile acids. These findings provide novel mechanistic insights and highlight YAP as a potential therapeutic target, offering new perspectives for bile acid-based intervention strategies in cholangiocarcinoma. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Hu J, Zhang G, Yang S, Shen XF, Zhou M, Huang LS, Lan HM. Involvement of bile acids in cholangiocarcinoma progression via the Hippo-yes-associated protein signaling pathway. World J Gastrointest Oncol 2025; 17(12): 112366 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/112366.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.112366 |
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