| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Basic Study |
| Article Title |
Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Sowbarnika Ravichandran, Jerly Helan Mary Joseph, Shanmugaapriya Sellathamby and Mahesh Kandasamy |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Science and Engineering Research Board |
No. SERB-EEQ/2016/000639 |
| The Faculty Recharge Programme, University Grants Commission (UGC-FRP) |
No. F4-5 (97)/2014 |
| Rashtriya Uchchatar Shiksha Abhiyan (RUSA) 2.0, Biological Sciences, Bharathidasan University |
No. TN RUSA: 311/RUSA (2.0)/2018 |
| Human Resource Development Group |
No. 111-3107-4868/2K24/1 |
| Infrastructure of the Department of Animal Science, Bharathidasan University |
No. UGC-SAP-DRS and No. DST-FIST |
| CSIR-SRF Direct |
No. 09/0475(23353)/2025-EMR-I |
|
| Corresponding Author |
Mahesh Kandasamy, Assistant Professor, Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli – 620024, Tamilnadu, India., Tiruchirappalli 620024, Tamil Nadu, India. mahesh.kandasamy@bdu.ac.in |
| Key Words |
Coagulation; Prothrombin time; Platelet aggregation; Tail bleeding; Botulinum toxin |
| Core Tip |
Botulinum toxin (BoNT), widely known for its therapeutic use in neurological and psychiatric disorders. It may also influence blood biochemical parameters, including hemostatic processes, as BoNT has been reported to increase platelet count, which, in turn, could play a role in regulating blood coagulation. This study demonstrates that a single mild intramuscular dose of BoNT significantly reduces bleeding time following tail transection by enhancing platelet aggregation and promoting robust fibrin clot formation. These findings highlight a novel antihemorrhagic property of BoNT, suggesting its potential application in managing bleeding complications in trauma, surgical interventions, or hemorrhagic disorders. |
| Publish Date |
2025-12-04 06:40 |
| Citation |
Ravichandran S, Joseph JHM, Sellathamby S, Kandasamy M. Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice. World J Biol Chem 2025; 16(4): 112376 |
| URL |
https://www.wjgnet.com/1949-8454/full/v16/i4/112376.htm |
| DOI |
https://dx.doi.org/10.4331/wjbc.v16.i4.112376 |
