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11/26/2025 4:02:02 AM | Browse: 7 | Download: 15
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Received |
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2025-07-31 02:30 |
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Peer-Review Started |
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2025-07-31 02:30 |
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To Make the First Decision |
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Return for Revision |
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2025-08-05 08:42 |
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Revised |
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2025-08-18 05:52 |
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Second Decision |
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2025-10-31 10:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-11-03 10:08 |
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Articles in Press |
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2025-11-03 10:08 |
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Publication Fee Transferred |
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2025-08-23 23:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-19 01:20 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Jun Tu, Yun-Qi Liu, Yan-Yan Pan, Hong-Yang Cai and Chang Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Department of Science & Technology of Liaoning Province |
2024-MS-285 |
| National Natural Science Foundation of China |
82303572 |
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| Corresponding Author |
Chang Liu, Affiliate Associate Professor, PhD, /, Central Hospital of Dalian University of Technology, No. 826 Southwest Road, Dalian 116033, Liaoning Province, China. liuch2024@dlut.edu.cn |
| Key Words |
Tendon-derived stem cells; Thymoquinone; Chondrogenic differentiation; Endoplasmic reticulum stress; Tendinopathy |
| Core Tip |
In our previous investigation, we demonstrated that micro-injured tendon with 6.4% strain promoted the chondrogenic differentiation of tendon-derived stem cells, by activating endoplasmic reticulum (ER) stress. To further validate this phenomenon in the animal model, we established a rat Achilles tendon injury model via treadmill running. In the present study, tendon injury was found to activate ER stress by upregulating the protein kinase RNA-like ER kinase/eukaryotic initiation factor 2/activating transcription factor 4/CCAAT/enhancer-binding protein homologous protein pathway, and thymoquinone was shown to alleviate ER stress, while inhibiting the chondrogenic differentiation of tendon-derived stem cells both in vitro and in vivo models. These findings suggested that thymoquinone may hold potential as a preventive and therapeutic agent for tendinopathy. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
<p>Tu YJ, Liu YQ, Pan YY, Cai HY, Liu C. Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury. <i>World J Stem Cells</i> 2025; 17(11): 112393</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/112393.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.112393 |
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