| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Fei Feng, Tu-Mei Su, Bo-Bin Hu, Hang Wang, Qing-Mei Li, Qian-Bing Yin, Long Huang, Hong-Qian Liang, Ao-Li Ren, Ming-Hua Su and Jian-Ning Jiang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81960115 |
| National Natural Science Foundation of China (General Program) |
82160123 |
| National Natural Science Foundation of China (General Program) |
82260124 |
| Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education |
No. GKE-ZZ202107 |
| Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor |
No. GKE-ZZ202218 |
| Guangxi Science and Technology Program |
No. AD25069077 |
|
| Corresponding Author |
Jian-Ning Jiang, Chief Physician, MD, PhD, Professor, Department of Infectious Diseases, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxjjianning@163.com |
| Key Words |
Hepatocellular carcinoma; Hepatitis B virus; Origin recognition complex subunit 1; Diagnostic biomarker; Alpha-fetoprotein-negative; Enzyme-linked immunosorbent assay |
| Core Tip |
This study identifies serum origin recognition complex subunit 1 (ORC1) as a novel diagnostic biomarker for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). ORC1 levels were markedly elevated in HBV-HCC patients, especially those negative for alpha-fetoprotein. Mechanistically, recurrent HBV integration near the ORC1 locus appears to drive its aberrant expression, contributing to hepatocarcinogenesis. These findings highlight ORC1 as a promising biomarker that complements alpha-fetoprotein, substantially improving early detection accuracy and offering strong potential for clinical translation in HBV-HCC screening. |
| Publish Date |
2025-11-28 03:10 |
| Citation |
<p>Feng YF, Su TM, Hu BB, Wang H, Li QM, Yin QB, Huang L, Liang HQ, Ren AL, Su MH, Jiang JN. Diagnostic performance of serum origin recognition complex subunit 1 protein for hepatitis B virus-related hepatocellular carcinoma. <i>World J Gastroenterol</i> 2025; 31(44): 112481</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i44/112481.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i44.112481 |
