BPG is committed to discovery and dissemination of knowledge
Featured Articles
11/26/2025 4:02:02 AM | Browse: 11 | Download: 15
 |
Received |
|
2025-07-28 14:42 |
|
Peer-Review Started |
|
2025-07-28 14:42 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2025-08-19 09:26 |
|
Revised |
|
2025-09-02 11:05 |
|
Second Decision |
|
2025-09-29 00:37 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2025-10-09 08:11 |
|
Articles in Press |
|
2025-10-09 08:11 |
|
Publication Fee Transferred |
|
2025-09-03 06:29 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-11-20 02:13 |
|
Publish the Manuscript Online |
|
2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
HIF-1α modulates β-catenin pathway to enhance the survival and angiogenesis of PBMSCs under hypoxia environment
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Zhen Wang, Ai-Qun Wang, Ping-Ge Tian, Ping-Ping Zhu, Wei Yuan, Jian Wu and Rui Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Natural Science Foundation General Program |
2025A1515012455 |
| Guangzhou Municipal Science and Technology Project |
2024A03J0653, 2023A03J0595 |
| Guangzhou Municipal Science and Technology Project |
2023A03J0510, 2023A03J0528 |
|
| Corresponding Author |
Rui Zhang, Chief Physician, MD, Department of Emergency, Guangzhou Red Cross Hospital of Jinan University, No. 396 Tongfu Middle Road, Guangzhou 510220, Guangdong Province, China. 63281796@qq.com |
| Key Words |
Angiogenesis; Hypoxia-inducible factor-1α; Myocardial infarction; Peripheral blood mesenchymal stem cells; β-catenin |
| Core Tip |
The finding of this study indicates that hypoxia-inducible factor-1α (HIF-1α) and β-catenin facilitate peripheral blood mesenchymal stem cells (PBMSCs) self-renewal and inhibit PBMSCs apoptosis. In vivo, PBMSCs with upregulated HIF-1α achieved enhanced retention within infarcted myocardial and contributed markedly to myocardial regeneration. These observations highlight the modulatory role of HIF-1α in modulating PBMSCs function via β-catenin-dependent anti-apoptotic and pro-angiogenic pathway, thereby offering a potential strategy to improve the longevity and therapeutic efficacy of PBMSCs. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
<p>Wang PZ, Wang AQ, Tian PG, Zhu PP, Yuan W, Wu J, Zhang R. HIF-1α modulates β-catenin pathway to enhance the survival and angiogenesis of PBMSCs under hypoxia environment. <i>World J Stem Cells</i> 2025; 17(11): 112484</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/112484.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.112484 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
