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11/28/2025 5:48:52 AM | Browse: 25 | Download: 34
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Received |
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2025-07-30 02:25 |
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Peer-Review Started |
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2025-07-30 02:25 |
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To Make the First Decision |
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Return for Revision |
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2025-09-03 09:29 |
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Revised |
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2025-09-13 18:52 |
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Second Decision |
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2025-10-20 02:53 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-20 06:36 |
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Articles in Press |
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2025-10-20 06:36 |
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Publication Fee Transferred |
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2025-09-16 09:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-21 07:13 |
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Publish the Manuscript Online |
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2025-11-28 03:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ismail Taskiran, Seda Orenay-Boyacioglu, Olcay Boyacioglu, Ibrahim Halil Erdogdu, Nil Culhaci and Ibrahim Meteoglu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Olcay Boyacioglu, Associate Professor, PhD, Faculty of Engineering, Aydin Adnan Menderes University, Merkez Kampus, Efeler, Aydin 09010, Türkiye. oboyaci@adu.edu.tr |
| Key Words |
DNA polymerase epsilon mutation; Non-exonuclease domain variants; Microsatellite instability; Colorectal cancer; Next-generation sequencing; Somatic co-mutations |
| Core Tip |
This study highlights the overlooked role of DNA polymerase epsilon (POLE) non-exonuclease domain mutations in colorectal cancer. By integrating next-generation sequencing with microsatellite instability testing, we show that POLE mutations are frequent, particularly in microsatellite-low tumors, and are often accompanied by co-mutations in MLH3, MSH3, KRAS, PIK3CA, and BRAF. These findings extend beyond the classical exonuclease domain hotspots, suggesting that both exonuclease and non-exonuclease POLE variants may serve as valuable biomarkers for prognosis and support the development of personalized treatment strategies in colorectal cancer management. |
| Publish Date |
2025-11-28 03:10 |
| Citation |
<p>Taskiran I, Orenay-Boyacioglu S, Boyacioglu O, Erdogdu IH, Culhaci N, Meteoglu I. DNA polymerase epsilon-mutant colorectal cancers: Insights into non-exonuclease domain mutation variants, microsatellite instability status, and co-mutation profiles. <i>World J Gastroenterol</i> 2025; 31(44): 112524</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i44/112524.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i44.112524 |
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