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12/3/2025 9:14:51 AM | Browse: 20 | Download: 44
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Received |
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2025-08-04 06:40 |
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Peer-Review Started |
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2025-08-04 06:40 |
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First Decision by Editorial Office Director |
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2025-08-14 11:28 |
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Return for Revision |
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2025-08-14 11:28 |
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Revised |
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2025-09-04 00:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-27 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-27 06:34 |
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Articles in Press |
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2025-10-27 06:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-28 01:46 |
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Publish the Manuscript Online |
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2025-12-03 09:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Daram Yang, Bumseok Kim and Jong-Won Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Science Research Program through the National Research Foundation of Korea (NRF), Funded by the Ministry of Education |
RS-2023-00275922 |
| Ministry of Science and ICT, Republic of Korea |
RS-2025-00556031 |
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| Corresponding Author |
Jong-Won Kim, Assistant Professor, PhD, Department of Pharmacology, Institute of Medical Sciences, College of Medicine, Gyeongsang National University, 15, Jinjudae-ro 816 Beon-gil, Jinju 52727, South Korea. kimjw@gnu.ac.kr |
| Key Words |
Acetaminophen; Acute liver injury; Hepatocyte; Immune cell; Liver |
| Core Tip |
This review provides a comprehensive overview of the cellular mechanisms underlying acetaminophen (APAP)-induced acute liver injury (ALI). It highlights the distinct yet interconnected roles of hepatocytes, Kupffer cells, monocyte-derived macrophages, hepatic stellate cells, liver sinusoidal endothelial cells, and adaptive immune cells in the initiation and progression of ALI. The review also explores how these cells contribute to both liver injury and repair, offering insight into the dynamic cellular crosstalk during APAP hepatotoxicity. By integrating recent findings, it identifies potential therapeutic targets and strategies that modulate cell-specific responses to improve clinical outcomes in drug-induced liver injury. |
| Publish Date |
2025-12-03 09:10 |
| Citation |
Yang D, Kim B, Kim JW. Mechanistic insights into hepatic cell type-specific contributions to acetaminophen-induced acute liver injury. World J Gastroenterol 2025; 31(45): 112720 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i45/112720.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i45.112720 |
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