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12/11/2025 8:26:15 AM | Browse: 150 | Download: 343
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Received |
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2025-08-05 00:49 |
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2025-08-05 00:49 |
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2025-08-22 08:31 |
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2025-09-28 12:36 |
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Second Decision by Editor |
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2025-11-12 02:49 |
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Final Decision by Editorial Office Director |
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2025-11-12 09:57 |
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Articles in Press |
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2025-11-12 09:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 02:48 |
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Publish the Manuscript Online |
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2025-12-11 08:21 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Interlaced roles of mitochondrial DNA in colorectal cancer: Liquid-biopsy biomarkers, nuclear mtDNA-driven genomic instability, and mito-encoded micro peptide signaling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Thai-Hau Koo, Xue-Bin Leong, Yi-Lin Lee, Firdaus Hayati and Andee Dzulkarnaen Zakaria |
| Funding Agency and Grant Number |
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| Corresponding Author |
Andee Dzulkarnaen Zakaria, Department of Surgery, Hospital Pakar Universiti Sains Malaysia, School of Medical Sciences, Jalan Raja Perempuan Zainab 2, Kubang Kerian 16150, Kelantan, Malaysia. andee@usm.my |
| Key Words |
Proteomic; Multi-omics; Gastrointestinal malignancy; Precision oncology; Biomarker discovery; Therapeutic resistance |
| Core Tip |
This minireviews highlights the emerging roles of mitochondrial DNA (mtDNA) in colorectal cancer beyond its role in energy metabolism. Three interrelated domains are focused on in this paper: (1) Cell-free mtDNA as a liquid biopsy biomarker of exceptional sensitivity; (2) Nuclear mtDNA fragments as a component of genomic instability; and (3) Mitochondria-derived peptides, such as humanin and mitochondrial open reading frame of the 12S rRNA type-c, as regulators of tumour behaviour. These insights reveal novel diagnostic and therapeutic potential by targeting mitochondrial-nuclear cross-talk in colorectal cancer. |
| Publish Date |
2025-12-11 08:21 |
| Citation |
Koo TH, Leong XB, Lee YL, Hayati F, Zakaria AD. Interlaced roles of mitochondrial DNA in colorectal cancer: Liquid-biopsy biomarkers, nuclear mtDNA-driven genomic instability, and mito-encoded micro peptide signaling. World J Gastrointest Oncol 2025; 17(12): 112753 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/112753.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.112753 |
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