| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Yuan Chen, Zhe Ji, Kang Guo, Hao-Nan Wang, Chen-Chen Zhu, Tao Li, Xiang-Bin Zhao, Yu-Ting Wang, Qiang Li, Pei-Sheng Jin and Xue-Yang Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82172224 |
| Xuzhou Health Commission Science and Technology Project |
No. XWKYHT20220136 |
| Xuzhou Health Commission Youth Project |
No. XWKYHT20220145 |
|
| Corresponding Author |
Xue-Yang Li, Associate Professor, Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University, Huai-hai West Road, Xuzhou 221006, Jiangsu Province, China. lmlxy240923@163.com |
| Key Words |
Fractional carbon dioxide; Photothermal effect; Mesenchymal stem cells; Exosomes; Sphingosine-1-phosphate; Diabetic wound |
| Core Tip |
In this study, adipose-derived mesenchymal stem cells were preconditioned with low-energy fractional carbon dioxide laser irradiation, utilizing a controlled photothermal effect to enhance the bioactivity of their secreted exosomes. These exosomes exhibited elevated levels of sphingosine-1-phosphate and significantly promoted endothelial cell proliferation, migration, and tube formation through activation of the sphingosine-1-phosphate receptor 1 protein kinase B/hypoxia-inducible factor 1 alpha signaling pathway, ultimately accelerating diabetic wound healing in vivo. |
| Publish Date |
2026-01-14 08:09 |
| Citation |
Chen JY, Ji Z, Guo K, Wang HN, Zhu CC, Li T, Zhao XB, Wang YT, Li Q, Jin PS, Li XY. Fractional carbon dioxide laser-induced photothermal activation of mesenchymal stem cell-derived exosomes accelerates diabetic wound healing by enhancing angiogenesis. World J Diabetes 2026; 17(1): 112942 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i1/112942.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i1.112942 |
