Publication Name	World Journal of Stem Cells
Manuscript ID	113032
Country	China

Received	2025-08-13 01:15
Peer-Review Started	2025-08-13 01:15
To Make the First Decision
Return for Revision	2025-09-08 09:54
Revised	2025-09-21 17:28
Second Decision	2025-11-12 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-12 03:29
Articles in Press	2025-11-12 03:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-11-20 02:15
Publish the Manuscript Online	2025-11-26 03:57

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Editorial
Article Title	Mitochondrial regulation of stem cell osteogenic differentiation: A key driver for bone regeneration
Manuscript Source	Invited Manuscript
All Author List	Jing-Shun Lu, Yun-Hong Zhao, Fei-Yan Mu, Chen-Yu Song, Min Yang, Yuan-Sheng Huang and Kai-Yang Wang
Funding Agency and Grant Number
Corresponding Author	Kai-Yang Wang, MD, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com
Key Words	Mesenchymal stem cells; Mitochondrial; Bone regeneration; Oxidative stress; Mitophagy
Core Tip	Mesenchymal stem cells (MSCs) hold promise for bone regeneration, but their potential is limited by poor osteogenic differentiation. Mitochondria play a pivotal role in bone defect repair, where their functions in energy metabolism, oxidative stress, dynamics, and mitophagy significantly regulate the osteogenic differentiation of MSCs. This work elucidated the mechanisms and therapeutic strategies of mitochondrial-targeted interventions to enhance MSC osteogenic differentiation, providing novel perspectives for developing mitochondria-focused bone regenerative medicine.
Publish Date	2025-11-26 03:57
Citation	<p>Lu JS, Zhao YH, Mu FY, Song CY, Yang M, Huang YS, Wang KY. Mitochondrial regulation of stem cell osteogenic differentiation: A key driver for bone regeneration. <i>World J Stem Cells</i> 2025; 17(11): 113032</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i11/113032.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i11.113032

Full Article (PDF)	WJSC-17-113032-with-cover.pdf
Manuscript File	113032_Auto_Edited_020724.docx
Answering Reviewers	113032-answering-reviewers.pdf
Audio Core Tip	113032-audio.m4a
Conflict-of-Interest Disclosure Form	113032-conflict-of-interest-statement.pdf
Copyright License Agreement	113032-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	113032-non-native-speakers.pdf
Supplementary Material	113032-supplementary-material.pdf
Peer-review Report	113032-peer-reviews.pdf
Scientific Misconduct Check	113032-scientific-misconduct-check.png
Scientific Editor Work List	113032-scientific-editor-work-list.pdf
CrossCheck Report	113032-crosscheck-report.pdf