Publication Name	World Journal of Gastroenterology
Manuscript ID	113170
Country	China

Received	2025-08-18 01:07
Peer-Review Started	2025-08-18 01:07
To Make the First Decision
Return for Revision	2025-08-27 09:49
Revised	2025-09-11 04:04
Second Decision	2025-10-20 02:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 06:03
Articles in Press	2025-10-20 06:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-10-29 02:33
Publish the Manuscript Online	2025-11-13 06:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Lie Zheng, Sheng-Lei Duan and Kai Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82574996 Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project TZKN-CXRC-16 Project of Shaanxi Administration of Traditional Chinese Medicine SZY-KJCYC-2025-JC-010 Shaanxi Province Key Research and Development Plan Project-Social Development Field 2025SF-YBXM-498 “Nursery Cultivation Plan” Project of Shaanxi Provincial Academy of Chinese Medicine and Shaanxi Provincial Hospital of Traditional Chinese Medicine 2025-04 The Fifth Batch of Outstanding Clinical Talents in Traditional Chinese Medicine Project of Shaanxi Province
Corresponding Author	Kai Wang, /, Shaanxi Second Provincial People’s Hospital, No. 3 Shangqin Road, Xi’an 710005, Shaanxi Province, China. wangkaiyisheng@163.com
Key Words	Inflammatory bowel disease; Intestinal microbiota; Intestinal barrier; Metagenomics; Metabolomics
Core Tip	The etiology of inflammatory bowel disease (IBD) is complex and involves multiple factors working together, including genetic, environmental, dietary, immune and neurological factors. These factors are interrelated through a complex gut microbiome composed of bacteria, fungi, archaea, viruses and protozoa. Gut microbiota play a core role in IBD, such as genetic and serum markers related to host-gut microbiota interactions, alterations in gut microbiota in first-degree relatives, and the dynamic recovery of gut microbiota that accompanies the remission of inflammation. In fact, the rising incidence of IBD worldwide is closely related to changes in a series of environmental factors that typically affect gut microbiota. In recent years, advancements in multi-omics technologies such as metagenomics, metatranscriptomics and metabolomics, as well as their application in mouse models, human, fungal and bacterial cells, have further deepened our understanding of the role of gut microbiota in IBD.
Publish Date	2025-11-13 06:51
Citation	<p>Zheng L, Duan SL, Wang K. Research progress concerning the involvement of the intestinal microbiota in the occurrence and development of inflammatory bowel disease. <i>World J Gastroenterol</i> 2025; 31(42): 113170</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i42/113170.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i42.113170

Full Article (PDF)	WJG-31-113170-with-cover.pdf
Manuscript File	113170_Auto_Edited_041605.docx
Answering Reviewers	113170-answering-reviewers.pdf
Audio Core Tip	113170-audio.m4a
Conflict-of-Interest Disclosure Form	113170-conflict-of-interest-statement.pdf
Copyright License Agreement	113170-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	113170-non-native-speakers.pdf
Peer-review Report	113170-peer-reviews.pdf
Scientific Misconduct Check	113170-scientific-misconduct-check.png
Scientific Editor Work List	113170-scientific-editor-work-list.pdf
CrossCheck Report	113170-crosscheck-report.pdf