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11/21/2025 4:16:37 AM | Browse: 8 | Download: 64
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Received |
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2025-08-19 01:36 |
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Peer-Review Started |
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2025-08-19 01:37 |
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To Make the First Decision |
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Return for Revision |
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2025-08-26 09:48 |
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Revised |
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2025-08-30 15:28 |
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Second Decision |
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2025-10-27 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-10-27 06:08 |
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Articles in Press |
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2025-10-27 06:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-14 01:55 |
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Publish the Manuscript Online |
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2025-11-21 03:54 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
When new therapies arrive, we should think more: The unseen challenges of immunotherapy-induced remodeling
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rui-Gang Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Tsinghua Changgung Hospital Youth Fund |
12021C1011 |
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| Corresponding Author |
Rui-Gang Wang, Department of Gastroenterology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No. 168 Litang Road, Changping District., Beijing 102218, China. doctorwrg@163.com |
| Key Words |
Immune checkpoint inhibitors; Microsatellite instability-high colorectal cancer; Tissue remodeling; Pathological complete response; Toxicity |
| Core Tip |
The unprecedented case of spontaneous colonic transection after pathological complete response to pembrolizumab in microsatellite instability-high colorectal cancer highlights a critical blind spot in immune oncology. While immune checkpoint inhibitors achieve remarkable tumor regression, they can induce profound bowel wall damage invisible to conventional imaging. This editorial calls for urgent multidisciplinary action: Re-evaluating surgical timing and techniques in immunotherapy responders, developing novel biomarkers to predict bowel wall integrity, and implementing enhanced surveillance protocols to prevent catastrophic complications from delayed tissue toxicity. |
| Publish Date |
2025-11-21 03:54 |
| Citation |
<p>Wang RG. When new therapies arrive, we should think more: The unseen challenges of immunotherapy-induced remodeling. <i>World J Clin Cases</i> 2025; 13(33): 113216</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i33/113216.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i33.113216 |
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