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12/11/2025 8:26:15 AM | Browse: 21 | Download: 52
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Received |
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2025-08-31 05:53 |
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Peer-Review Started |
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2025-08-31 05:53 |
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First Decision by Editorial Office Director |
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2025-09-12 05:36 |
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Return for Revision |
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2025-09-12 05:36 |
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Revised |
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2025-09-25 04:24 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-28 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-28 07:38 |
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Articles in Press |
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2025-10-28 07:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 00:27 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Molecular mechanism of non-coding RNAs-mediated radiosensitivity regulation in colorectal cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao Li, Xiu-Xia Hao, Rui-Qing Zhu and Hong-Wei Zhou |
| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao Li, MD, PhD, Department of General Medicine, The Fourth Medical Center of Chinese PLA General Hospital, No. 51 Fucheng Road, Haidian District, Beijing 100048, China. nklx@foxmail.com |
| Key Words |
Radiosensitivity; Noncoding RNAs; Colorectal cancer; Radiotherapy; Radioresistance |
| Core Tip |
Colorectal cancer (CRC), a leading cause of cancer mortality, shows less than 10% 5-year survival in advanced stages and radiotherapy is crucial for advanced CRC patients. Noncoding RNAs (ncRNAs), including microRNAs, long ncRNAs and circular RNAs, significantly influence CRC radiosensitivity through diverse mechanisms like epithelial-mesenchymal transition, epigenetic reprogramming, post-transcriptional regulation and oncogenic signaling pathways activation. They show promise as biomarkers for predicting radiosensitivity and prognosis, and as therapeutic targets to overcome radioresistance. Targeting ncRNA-mediated networks offers promising strategies to overcome radioresistance and improve outcomes, bridging molecular mechanisms with precision radiotherapy for advanced CRC. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Li X, Hao XX, Zhu RQ, Zhou HW. Molecular mechanism of non-coding RNAs-mediated radiosensitivity regulation in colorectal cancer. World J Gastrointest Oncol 2025; 17(12): 113636 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/113636.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.113636 |
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