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12/25/2025 9:07:32 AM | Browse: 1 | Download: 0
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Received |
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2025-09-01 06:46 |
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Peer-Review Started |
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2025-09-01 06:46 |
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First Decision by Editorial Office Director |
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2025-10-17 07:28 |
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Return for Revision |
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2025-10-17 07:28 |
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Revised |
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2025-10-31 06:39 |
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Second Decision by Editor |
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2025-12-15 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-15 07:01 |
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Articles in Press |
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2025-12-15 07:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-23 01:44 |
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Publish the Manuscript Online |
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2025-12-25 08:54 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Case Report |
| Article Title |
First use of nitazoxanide in Kelleni’s protocol for managing severe bronchiolitis in a 9-month-old infant: A case report and review of literature
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mina Thabet Kelleni |
| Funding Agency and Grant Number |
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| Corresponding Author |
Mina Thabet Kelleni, Assistant Professor, MD, PhD, Department of Medical Pharmacology, College of Medicine, Minia University, Main Road Shalaby Land, Minya 61519, Egypt. mina.kelleni@mu.edu.eg |
| Key Words |
SARS-CoV-2; COVID-19; Nitazoxanide; Benproperine; Alpha-amylase; Levocetrizine; Ambroxol; Kelleni’s protocol; Case report |
| Core Tip |
This report presents the first documented use of nitazoxanide incorporated within Kelleni’s protocol to manage severe bronchiolitis in a 9-month-old infant. The infant presented with SpO₂ 84% on room air, tachypnea, and diffuse wheezing which was clinically consistent with severe viral bronchiolitis. Bronchiolitis is a leading cause of infant hospitalization and mortality worldwide, with limited effective antiviral treatments. Early administration of nitazoxanide, alongside other immunomodulatory therapies, showed clinical improvement as shown with resolution of fever and progressive improvement in in all symptoms, SpO₂ rising from 84% to 92% and then 96% at full recovery in this severe case within two weeks. This approach highlights the potential to repurpose nitazoxanide and Kelleni’s protocol to safely manage severe lower viral respiratory tract infections in infants younger than one year. |
| Publish Date |
2025-12-25 08:54 |
| Citation |
Kelleni MT. First use of nitazoxanide in Kelleni’s protocol for managing severe bronchiolitis in a 9-month-old infant: A case report and review of literature. World J Clin Cases 2025; 13(36): 113655 |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i36/113655.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i36.113655 |
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