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2/12/2026 11:23:28 AM | Browse: 4 | Download: 11
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Received |
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2025-09-10 08:35 |
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Peer-Review Started |
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2025-09-10 08:36 |
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First Decision by Editorial Office Director |
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2025-10-13 08:51 |
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Return for Revision |
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2025-10-13 08:51 |
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Revised |
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2025-10-21 06:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-16 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-16 09:33 |
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Articles in Press |
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2025-12-16 09:33 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 00:38 |
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Publish the Manuscript Online |
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2026-02-12 11:20 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Should the theory of methotrexate-induced liver toxicity be abandoned?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yahya Al-Hammada, Sinan Sharba and Samer Al-Dury |
| Funding Agency and Grant Number |
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| Corresponding Author |
Samer Al-Dury, MD, PhD, School of Public Health and Community Medicine, University of Gothenburg, Universitetsplatsen 1, Gothenburg 40530, Sweden. samer.al-dury@gu.se |
| Key Words |
Risk stratification; Noninvasive monitoring; Metabolic risk factors; Hepatotoxicity; Liver fibrosis; Methotrexate |
| Core Tip |
Methotrexate (MTX) has long been associated with a presumed risk of hepatotoxicity and progressive liver fibrosis, largely based on early biopsy-era studies. Contemporary evidence using non-invasive fibrosis assessment shows that significant fibrosis is uncommon in MTX-treated patients and more strongly linked to metabolic dysfunction-associated steatotic liver disease and related risk factors such as obesity, diabetes, and insulin resistance. This minireview challenges the traditional perception of intrinsic MTX hepatotoxicity and argues for risk-based rather than drug-based monitoring strategies. |
| Publish Date |
2026-02-12 11:20 |
| Citation |
Al-Hammada Y, Sharba S, Al-Dury S. Should the theory of methotrexate-induced liver toxicity be abandoned? World J Hepatol 2026; 18(2): 113743 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i2/113743.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i2.113743 |
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