| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
MiR-27b-5p promotes gastric cancer progression by targeting CREBZF to regulate the STAT3 pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Chao Ma, Guan-Lan Zhang, Guo-Qiang Chen, Jing-Wen Ling, Yu-Feng Li, Bang-Teng Chi, Yu-Lu Tang, Wei Peng, Gang Chen, Dan-Ming Wei, Min-Hua Rong and Lian-Ying Ge |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project |
Z-A20220465 |
| Guangxi Key Research and Development Plan |
AB20297021 |
| Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project |
S2022107 |
| China Undergraduate Innovation and Entrepreneurship Training Program |
S202310598074 |
| Future Academic Star of Guangxi Medical University |
WLXSZX23109 |
|
| Corresponding Author |
Lian-Ying Ge, Department of Endoscopy, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxgly@hotmail.com |
| Key Words |
Gastric cancer; MiR-27b-5p; cAMP response element-binding protein zinc finger; Signal transducer and activator of transcription 3 pathway; MicroRNAs |
| Core Tip |
Our findings provide preliminary evidence that reduction of miR-27b-5p restrains proliferation and migration of gastric cancer cells. Our investigation also indicates that elevated expression level of miR-27b-5p suppresses gene expression related to the signal transducer and activator of transcription 3 signaling pathway, mainly targeting cAMP response element-binding protein zinc finger. Specifically, this regulatory process includes upregulation of signal transducer and activator of transcription 3, cellular myelocytomatosis oncogene, cyclin D1, B-cell lymphoma 2, and survivin, as well as the downregulation of Bcl-2-associated X protein, Bcl-2-associated X protein/B-cell lymphoma 2 ratio, and cAMP response element-binding protein zinc finger. These molecular mechanisms enhance the proliferation of gastric cancer cells. |
| Publish Date |
2026-03-12 12:25 |
| Citation |
Ma FC, Zhang GL, Chen GQ, Ling JW, Li YF, Chi BT, Tang YL, Peng W, Chen G, Wei DM, Rong MH, Ge LY. MiR-27b-5p promotes gastric cancer progression by targeting CREBZF to regulate the STAT3 pathway. World J Gastrointest Oncol 2026; 18(3): 113781 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i3/113781.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i3.113781 |
