Publication Name	World Journal of Gastroenterology
Manuscript ID	113793
Country	China

Received	2025-09-03 08:45
Peer-Review Started	2025-09-03 08:46
To Make the First Decision
Return for Revision	2025-09-12 08:51
Revised	2025-09-20 12:08
Second Decision	2025-10-22 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-22 03:30
Articles in Press	2025-10-22 03:30
Publication Fee Transferred	2025-10-11 15:16
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-11-21 07:11
Publish the Manuscript Online	2025-11-28 03:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Advances in the study of the relationship between neurotransmitters and gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	You-Zhao Liu, Wen-Xuan Liu and Wen-Hong Deng
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82172855
Corresponding Author	Wen-Hong Deng, Chief Physician, Full Professor, PhD, Gastrointestinal Surgery, wuhan university of renmin hospital, No. 99 Zhangzhidong Road, Wuchang District, Wuhan City, Hubei Province, wuhan 430000, Hubei, China. wenhongdeng@whu.edu.cn
Key Words	Neurotransmitters; Gastric cancer; Signaling pathway transmission; Neuro-immune regulation; Tumor microenvironment
Core Tip	The nervous system plays a critical but underrecognized role in gastric cancer (GC) progression through bidirectional neuro-tumoral interactions. Neurotransmitters—including norepinephrine, acetylcholine, glutamate, γ-aminobutyric acid, adenosine, and neuropeptide Y—produced by both neurons and malignant cells, actively reprogram the tumor microenvironment. These mediators regulate proliferation, invasion, metastasis, immune evasion, and therapeutic resistance in GC. This review highlights advances in understanding neurotransmitter-driven mechanisms and introduces the concept of “neuro-gastric oncology,” providing a rationale for novel therapeutic strategies targeting neuro-tumoral signaling pathways.
Publish Date	2025-11-28 03:10
Citation	<p>Liu YZ, Liu WX, Deng WH. Advances in the study of the relationship between neurotransmitters and gastric cancer. <i>World J Gastroenterol</i> 2025; 31(44): 113793</p>
URL	https://www.wjgnet.com/1007-9327/full/v31/i44/113793.htm
DOI	https://dx.doi.org/10.3748/wjg.v31.i44.113793

Full Article (PDF)	WJG-31-113793-with-cover.pdf
Manuscript File	113793_Auto_Edited_031147.docx
Answering Reviewers	113793-answering-reviewers.pdf
Audio Core Tip	113793-audio.m4a
Conflict-of-Interest Disclosure Form	113793-conflict-of-interest-statement.pdf
Copyright License Agreement	113793-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate	113793-non-native-speakers.pdf
Supplementary Material	113793-supplementary-material.pdf
Peer-review Report	113793-peer-reviews.pdf
Scientific Misconduct Check	113793-scientific-misconduct-check.png
Scientific Editor Work List	113793-scientific-editor-work-list.pdf
CrossCheck Report	113793-crosscheck-report.pdf