| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Han Li, Zhi-Peng Li, Meng-Ting Zhu, Chen-Hao Lan, Yu-Xin Wang, Ping Liao, Zheng Chen, Peng Wang, Jin-Ke Sun, Zhen Shi, Peng-Yu Lu, Chao Lou and Guo-Hong Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jinhua Public Welfare Technology Application Research Project |
2025-4-229 |
| Zhejiang Province Medical and Health Science and Technology Plan |
2022KY1343 |
|
| Corresponding Author |
Guo-Hong Xu, Chief Physician, Professor, Department of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, No. 60 Wuning West Road, Jinhua 322100, Zhejiang Province, China. xgh316@163.com |
| Key Words |
Tendon-bone healing; Mesenchymal stem cells; Exosomes; Biomaterials; Preconditioning; Gene modification |
| Core Tip |
This review synthesizes advances optimizing mesenchymal stem cell-based therapy for tendon-bone healing, spanning metabolic or mechanical preconditioning, instructive biomaterials (aligned fibers, gradient mineralization, controlled release), gene/cargo engineering, and exosome-centered paracrine modulation. These strategies target persistent hurdles - poor homing/engraftment, lineage commitment at the fibrocartilaginous interface, hostile inflammatory milieu, and immunogenicity - while improving zonal enthesis regeneration and mechanical integration. We also highlight scalable manufacturing and safety/readout standardization as key enablers to translate robust efficacy from preclinical models to rigorous clinical trials. |
| Publish Date |
2025-12-25 03:52 |
| Citation |
Li H, Li ZP, Zhu MT, Lan CH, Wang YX, Liao P, Chen Z, Wang P, Sun JK, Shi Z, Lu PY, Lou C, Xu GH. Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions. World J Stem Cells 2025; 17(12): 114076 |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i12/114076.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i12.114076 |
