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1/5/2026 6:44:23 AM | Browse: 129 | Download: 339
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Received |
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2025-09-15 13:47 |
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Peer-Review Started |
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2025-09-15 13:48 |
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First Decision by Editorial Office Director |
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2025-10-13 09:30 |
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Return for Revision |
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2025-10-13 09:30 |
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Revised |
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2025-10-22 06:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-21 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-21 09:58 |
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Articles in Press |
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2025-11-21 09:58 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-25 11:35 |
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Publish the Manuscript Online |
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2026-01-05 03:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Peroxiredoxin 1, pyroptosis, and the emerging frontier in colorectal cancer therapy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Dharmendra Kumar Maurya |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dharmendra Kumar Maurya, PhD, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, 3-82-S, A-Block, Modular Laboratory, Mumbai 400085, Maharashtra, India. dkmaurya@barc.gov.in |
| Key Words |
Colorectal cancer; Peroxiredoxin 1; Pyroptosis; Damage-associated molecular pattern; Immunogenic cell death |
| Core Tip |
Peroxiredoxin 1, long regarded as an intracellular antioxidant that protect tumors from oxidative stress, assumes a paradoxical role in colorectal cancer therapy. He et al reveal that extracellular peroxiredoxin 1 acts as a damage-associated molecular pattern, activating the NOD-, LRR- and pyrin domain-containing protein 3 inflammasome/caspase-1/gasdermin D pathway to trigger pyroptosis. This lytic, pro-inflammatory death suppresses colorectal cancer proliferation, invasion, and migration while amplifying interleukin-1β/interleukin-18-mediated immune surveillance. Using patient cohorts, recombinant protein assays, and xenograft models, the study rigorously validates this mechanism. |
| Publish Date |
2026-01-05 03:46 |
| Citation |
Maurya DK. Peroxiredoxin 1, pyroptosis, and the emerging frontier in colorectal cancer therapy. World J Gastroenterol 2026; 32(1): 114184 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i1/114184.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i1.114184 |
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