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2/28/2026 8:01:04 AM | Browse: 3 | Download: 16
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Received |
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2025-09-15 04:40 |
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Peer-Review Started |
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2025-09-15 04:40 |
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First Decision by Editorial Office Director |
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2025-09-25 08:38 |
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Return for Revision |
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2025-09-25 08:38 |
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Revised |
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2025-10-07 18:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-16 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-16 07:03 |
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Articles in Press |
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2025-12-16 07:03 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-05 09:36 |
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Publish the Manuscript Online |
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2026-02-28 07:48 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
MicroRNAs in sepsis: Advances in diagnosis and prognostic monitoring
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Valeria Fraioli, Marco Sanvitti and Federico Bilotta |
| Funding Agency and Grant Number |
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| Corresponding Author |
Federico Bilotta, MD, PhD, Professor, Department of Anesthesiology and Intensive Care, University of Tor Vergata, Via Cracovia 50, Rome 00133, Lazio, Italy. bilotta@tiscali.it |
| Key Words |
Sepsis; Septic shock; Circulating microRNAs; Biomarkers; Diagnosis; Prognosis; Extracellular vesicles; Precision medicine |
| Core Tip |
Circulating microRNAs (miRNAs) are emerging as stable and specific biomarkers for sepsis and septic shock diagnosis, prognosis, and therapeutic monitoring. Recent studies validate miRNA-451a (miR-451a), miR-9-5p, miR-193b-5p, miR-135a, miR-155, and miR-182 as superior to conventional markers, reflecting disease severity and immune status. Future diagnostic strategies may benefit from combination miRNA panels, which could enhance accuracy and support precision medicine in sepsis care. Large multicenter studies and methodological standardization remain essential to ensure reproducibility and enable their integration into clinical practice. |
| Publish Date |
2026-02-28 07:48 |
| Citation |
Fraioli V, Sanvitti M, Bilotta F. MicroRNAs in sepsis: Advances in diagnosis and prognostic monitoring. World J Crit Care Med 2026; 15(1): 114225 |
| URL |
https://www.wjgnet.com/2220-3141/full/v15/i1/114225.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v15.i1.114225 |
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