| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Egypt’s metabolic dysfunction associated steatotic liver disease: Genetic and dietary nexus, shaping artificial intelligence driven healthier future
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mona Hegazy, Mona Fathy, Omar Ashoush, Samah Abdelshafy, Dalia Abdelfatah, Samar Saad, Sawsan Abd El-Moniem, Wesam Ibrahim, Osama Ashraf, Shereen Saleh, Tarek Ahmed, Ragab Adly, Ali Abdel-Wahab, Ahmed Ahmed, Shadia Hussein, Ahmed Othman and Ahmed Abdelghani |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Cairo University |
|
|
| Corresponding Author |
Mona Hegazy, MD, Professor, Department of Internal Medicine, Hepatology and Gastroenterology, Kasr Alainy School of Medicine, Cairo University, Kasr Alainy Street, Cairo 12556, Al Qahirah, Egypt. monahegazy@cu.edu.eg |
| Key Words |
Metabolic-dysfunction associated steatotic liver disease; Egypt; Epidemiology; PNPLA3; Metabolic syndrome; Nutrition |
| Core Tip |
Egypt faces the world’s highest reported metabolic dysfunction associated steatotic liver disease prevalence (67.7%), driven by synergistic metabolic, dietary, and genetic factors. Obesity (27.5 times the risk), insulin resistance, high intake of refined carbohydrates, and PNPLA3 variants (present in 48% of cases) create a perfect metabolic storm. Alarmingly, 22% of lean individuals are affected, challenging traditional risk paradigms. These findings necessitate the implementation of urgent nationwide screening programs, culturally adapted lifestyle interventions, and the integration of genetic risk assessment into preventive strategies to combat this growing public health crisis. |
| Publish Date |
2026-03-16 08:22 |
| Citation |
Hegazy M, Fathy M, Ashoush O, Abdelshafy S, Abdelfatah D, Saad S, Abd El-Moniem S, Ibrahim W, Ashraf O, Saleh S, Ahmed T, Adly R, Abdel-Wahab A, Ahmed A, Hussein S, Othman A, Abdelghani A. Egypt’s metabolic dysfunction associated steatotic liver disease: Genetic and dietary nexus, shaping artificial intelligence driven healthier future. World J Gastroenterol 2026; 32(11): 114243 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i11/114243.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i11.114243 |
