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1/21/2026 10:54:23 AM | Browse: 130 | Download: 414
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Received |
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2025-09-22 05:22 |
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Peer-Review Started |
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2025-09-22 05:23 |
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First Decision by Editorial Office Director |
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2025-10-13 07:13 |
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Return for Revision |
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2025-10-13 07:13 |
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Revised |
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2025-10-25 14:56 |
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Publication Fee Transferred |
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2025-10-28 04:12 |
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Second Decision by Editor |
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2025-11-13 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-13 07:20 |
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Articles in Press |
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2025-11-13 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-12 06:05 |
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Publish the Manuscript Online |
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2026-01-21 09:49 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Differences in testosterone levels in perianal diseases: A comparative study of abscesses and fistulas
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi Zhang, Qiang Zhang, Min-Jie Wang, Yan-Ting Sun and Jin-Gen Lu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jin-Gen Lu, Anorectal Department, Longhua Hospital, Shanghai University of Traditional of Chinses Medicine, No. 725, Wanping South Road, Xuhui District, Shanghai, China, Shanghai 200000, China. jingen.lu@shutcm.edu.cn |
| Key Words |
Perianal diseases; Testosterone; Sex hormones; Anorectal abscess; Anal fistula; Inflammation; Body mass index; Cross-sectional study |
| Core Tip |
This study challenges the classic high-androgen hypothesis in perianal infections by demonstrating that patients with active anorectal abscess exhibit a significantly lower testosterone (T) level compared to those with hemorrhoids or fistulas, which is independently associated with systemic inflammation and obesity. We propose two novel hypotheses, namely a dynamic shift from high to low T, and a pathogenic role of inherent low T. The new endocrinological perspective suggests that restoring T could be a future adjunctive therapeutic strategy. |
| Publish Date |
2026-01-21 09:49 |
| Citation |
Zhang X, Zhang Q, Wang MJ, Sun YT, Lu JG. Differences in testosterone levels in perianal diseases: A comparative study of abscesses and fistulas. World J Gastrointest Surg 2026; 18(1): 114445 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i1/114445.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i1.114445 |
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