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2/28/2026 8:46:19 AM | Browse: 6 | Download: 36
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Received |
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2025-09-19 11:33 |
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Peer-Review Started |
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2025-09-19 11:34 |
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First Decision by Editorial Office Director |
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2025-10-24 10:56 |
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Return for Revision |
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2025-10-24 10:56 |
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Revised |
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2025-11-06 13:04 |
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Publication Fee Transferred |
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2025-11-12 11:10 |
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Second Decision by Editor |
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2025-12-09 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-09 08:50 |
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Articles in Press |
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2025-12-09 08:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-10 09:10 |
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Publish the Manuscript Online |
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2026-02-28 08:32 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Du-Xing Li, Yi Gu, Wen-Juan Xia, Yi-Fan Sun, Lu Hou, Wen-Xian Zhu and Jun Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee |
No. BJ2023086 |
| Wuxi Taihu Talent Project |
No. WXTTP 2021 |
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| Corresponding Author |
Jun Wang, Department of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, No. 156 Qianrong Road, Binhu District, Wuxi 214151, Jiangsu Province, China. woodfish2@126.com |
| Key Words |
Anhedonia; Major depressive disorder; Probiotics; Inflammatory markers; Event-related potentials |
| Core Tip |
This study investigated whether Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depressive disorder through immune-inflammatory modulation and reward-related electrophysiological changes. The probiotic significantly reduced inflammatory markers (lipopolysaccharide, C-reactive protein, and interleukin-6) and enhanced reward anticipation, as reflected by increased stimulus-preceding negativity amplitude and higher Temporal Experience of Pleasure Scale scores. These results suggest that CCFM6432 may improve anhedonia via an immune-inflammatory pathway. Large-scale, multicenter studies integrating multimodal biomarkers are warranted to validate and extend these findings. |
| Publish Date |
2026-02-28 08:32 |
| Citation |
Li DX, Gu Y, Xia WJ, Sun YF, Hou L, Zhu WX, Wang J. Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis. World J Psychiatry 2026; 16(3): 114446 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i3/114446.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i3.114446 |
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