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1/12/2026 10:51:11 AM | Browse: 11 | Download: 50
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Received |
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2025-09-22 02:47 |
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Peer-Review Started |
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2025-09-22 02:48 |
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First Decision by Editorial Office Director |
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2025-10-21 06:24 |
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Return for Revision |
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2025-10-21 06:24 |
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Revised |
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2025-11-03 18:52 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-27 02:41 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-27 06:19 |
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Articles in Press |
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2025-11-27 06:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-04 02:06 |
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Publish the Manuscript Online |
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2026-01-12 10:07 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Editorial |
| Article Title |
Molecular mosaic of colorectal cancer: Why one classification system is no longer enough?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sunita Ahlawat and Sumanta Das |
| Funding Agency and Grant Number |
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| Corresponding Author |
Sumanta Das, Department of Pathology, Agilus Diagnostics Ltd, Fortis Memorial Research Institute, Sector 44, Opposite Huda City Centre, Gurugram 122002, Haryana, India. sumantad755@gmail.com |
| Key Words |
Consensus molecular subtypes; Heterogeneity; Colorectal cancer intrinsic subtypes; Pathway-derived subtypes; Clinical translation |
| Core Tip |
Colorectal cancer (CRC) is not a single disease but a molecular mosaic. The consensus molecular subtypes brought important progress, yet nearly a decade of experience highlights its limitations - heterogeneity, unclassified cases, and bulk transcriptomic biases. Emerging systems such as CRC intrinsic subtypes, pathway-derived subtypes, and stem cell-based frameworks reveal complementary biological perspectives. Precision oncology for CRC requires abandoning the search for one “best” classification and instead embracing a pluralistic, multi-omic, and adaptive taxonomy that aligns with distinct clinical needs. |
| Publish Date |
2026-01-12 10:07 |
| Citation |
Ahlawat S, Das S. Molecular mosaic of colorectal cancer: Why one classification system is no longer enough? World J Gastrointest Oncol 2026; 18(1): 114502 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i1/114502.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i1.114502 |
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