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2/28/2026 8:01:04 AM | Browse: 3 | Download: 13
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Received |
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2025-09-25 06:28 |
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Peer-Review Started |
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2025-09-25 06:28 |
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2025-10-21 07:23 |
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2025-10-21 07:23 |
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2025-11-21 19:24 |
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Second Decision by Editor |
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2026-01-26 02:45 |
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Final Decision by Editorial Office Director |
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2026-01-26 09:46 |
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Articles in Press |
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2026-01-26 09:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-09 00:36 |
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Publish the Manuscript Online |
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2026-02-28 07:48 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Dysregulation of renin-angiotensin-aldosterone axis in septic shock: Emerging roles of angiotensin-(1-5) and alamandine
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Arunkumaar Srinivasan and Ponnsusamy Dhivya |
| Funding Agency and Grant Number |
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| Corresponding Author |
Arunkumaar Srinivasan, Consultant, Department of GI and Renal Critical Care, Apollo Hospital, Greams Lane, Chennai 600006, Tamil Nadu, India. arundec06@gmail.com |
| Key Words |
Septic shock; Sepsis; Renin-angiotensin-aldosterone system; Angiotensin-(1-7); Angiotensin-(1-5); Alamandine |
| Core Tip |
Septic shock, as defined by sepsis-3, is a severe form of sepsis marked by high mortality, requiring vasopressors to maintain mean arterial pressure ≥ 65 mmHg and lactate > 2 mmol/L despite fluids. It involves circulatory and metabolic failure. Normally, the renin-angiotensin-aldosterone axis and sympathetic nervous system maintain vascular tone and volume. In septic shock, dysregulation occurs: Reduced angiotensin (Ang)-converting enzyme activity lowers Ang II and blunts vasoconstriction, while counter-regulatory pathways via Ang-converting enzyme 2-Ang-(1–7)-mas receptor promote vasodilation. Emerging metabolites like Ang-(1–5) and alamandine show cardioprotective roles, suggesting therapeutic potential in rebalancing renin-Ang-aldosterone signaling for refractory shock. |
| Publish Date |
2026-02-28 07:48 |
| Citation |
Srinivasan A, Dhivya P. Dysregulation of renin-angiotensin-aldosterone axis in septic shock: Emerging roles of angiotensin-(1-5) and alamandine. World J Crit Care Med 2026; 15(1): 114670 |
| URL |
https://www.wjgnet.com/2220-3141/full/v15/i1/114670.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v15.i1.114670 |
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