| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Dentistry, Oral Surgery & Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Human amniotic mesenchymal stem cell-derived small extracellular vesicles repair of jaw osteoradionecrosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Fei Zhou, Jia-Min Xu, Jie Li, Fan Xu, Jian-Feng Li, Yi Yu, Hua Yuan, Yi-Feng Bian, Yu-Li Wang and Yi-Fei Du |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangsu Province Capability Improvement Project Through Science, Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit |
YJXYYJSDW4 |
| Jiangsu Provincial Medical Innovation Center |
CXZX202227 |
| the Project Funded by Jiangsu Provincial Commission of Health and Family Planning |
BJ18035 |
| Nanjing Specific Program of Health and Technology Development |
YKK23295 |
|
| Corresponding Author |
Yi-Fei Du, Associate Professor, MD, PhD, Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital of Nanjing Medical University, No. 1 Shanghai Road, Nanjing 210029, Jiangsu Province, China. danxiangren2006@163.com |
| Key Words |
Human amniotic mesenchymal stem cells; Small extracellular vesicles; Osteoradionecrosis of the jaw; Osteogenesis; Angiogenesis; Phosphatidylinositol 3-kinase/protein kinase B signaling pathway; Wnt/β-catenin signaling pathway |
| Core Tip |
The small extracellular vesicles from human amniotic mesenchymal stem cells (hAMSCs-sEVs) enhanced tooth socket healing in rats with osteoradionecrosis of the jaw, increasing bone formation and expression of osteogenic (collagen-1, alkaline phosphatase) as well as angiogenic (CD31, vascular endothelial growth factor) markers. In vitro, hAMSCs-sEVs reversed the inhibition of osteogenesis and angiogenesis by reactivating the phosphatidylinositol 3-kinase/protein kinase B and Wnt/β-catenin signaling pathways, respectively, as confirmed by pathway inhibitors. These findings indicate that hAMSCs-sEVs facilitate osteoradionecrosis of the jaw bone healing by reversing radiation-impaired osteogenesis and angiogenesis via key signaling pathways. |
| Publish Date |
2026-03-25 08:45 |
| Citation |
Zhou HF, Xu JM, Li J, Xu F, Li JF, Yu Y, Yuan H, Bian YF, Wang YL, Du YF. Human amniotic mesenchymal stem cell-derived small extracellular vesicles repair of jaw osteoradionecrosis. World J Stem Cells 2026; 18(3): 114746 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i3/114746.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i3.114746 |
