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2/6/2026 9:20:43 AM | Browse: 11 | Download: 28
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Received |
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2025-10-20 01:49 |
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Peer-Review Started |
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2025-10-20 01:50 |
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First Decision by Editorial Office Director |
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2025-11-19 10:42 |
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Return for Revision |
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2025-11-19 10:42 |
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Revised |
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2025-11-28 14:22 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-19 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-19 09:28 |
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Articles in Press |
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2025-12-19 09:28 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-27 11:08 |
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Publish the Manuscript Online |
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2026-02-06 08:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Refining early detection of hepatocellular carcinoma: The promise of the GALAD score
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Harsha S Prakash, Amit Sehrawat, Anusha Mruthyunjaya Swamy and Deepak Sundriyal |
| Funding Agency and Grant Number |
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| Corresponding Author |
Amit Sehrawat, Department of Medical Oncology Haematology, All India Institute of Medical Sciences, Virbhadra Road, Rishikesh 249203, Uttarakhand, India. dramitsehrawat@gmail.com |
| Key Words |
Hepatocellular carcinoma; GALAD score; Alpha-fetoprotein; Des-gamma-carboxy prothrombin; Early detection; Biomarker algorithms; Liver cancer surveillance |
| Core Tip |
Compared to alpha-fetoprotein (AFP) and ultrasonography alone, the GALAD score, which takes into account age, sex, AFP, AFP-L3, and des-gamma-carboxy prothrombin, shows superior diagnostic effectiveness for hepatocellular carcinoma. However, different groups have different best cut-offs, which supports the idea that a global criterion is inappropriate. Future multi-ethnic prospective studies and integration with imaging (e.g., GALADUS) are necessary for the standardized, cost-effective detection of early hepatocellular carcinoma. |
| Publish Date |
2026-02-06 08:53 |
| Citation |
Prakash HS, Sehrawat A, Swamy AM, Sundriyal D. Refining early detection of hepatocellular carcinoma: The promise of the GALAD score. World J Gastroenterol 2026; 32(7): 115044 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i7/115044.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i7.115044 |
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