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2/28/2026 8:46:19 AM | Browse: 4 | Download: 15
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Received |
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2025-10-14 01:50 |
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Peer-Review Started |
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2025-10-14 01:50 |
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First Decision by Editorial Office Director |
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2025-10-31 07:37 |
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Return for Revision |
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2025-10-31 07:37 |
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Revised |
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2025-11-09 02:06 |
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Publication Fee Transferred |
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2025-11-11 11:52 |
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Second Decision by Editor |
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2025-12-12 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-12 09:08 |
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Articles in Press |
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2025-12-12 09:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-13 03:55 |
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Publish the Manuscript Online |
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2026-02-28 08:32 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychiatry |
| Manuscript Type |
Case Control Study |
| Article Title |
Electroconvulsive therapy alters serum cytokine levels and correlates with symptom improvement in patients with acute schizophrenia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li Xu, Xiao-Bin Zhang, Ling-Shu Luan, Man Yang, Jing Zhang, Hai-Dong Yang and Xiao-Wei Tang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Suzhou Clinical Medical Center for Mood Disorders |
No. Szlcyxzx202109 |
| Suzhou Key Laboratory |
No. SZS2024016 |
| Suzhou Multicenter Clinical Research Project on Major Diseases |
No. DZXYJ202413 |
| Guidance Project of Jiangsu Provincial Health Commission |
No. Z2023074 |
| Yangzhou Basic Research Program (Joint Special Project) Health Project |
No. 2024-2-19 |
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| Corresponding Author |
Xiao-Wei Tang, Chief Physician, MD, PhD, Department of Psychiatry, Yangzhou Wutaishan Hospital of Jiangsu Province, No. 2 Wutaishan Road, Yangzhou 225003, Jiangsu Province, China. 15062790442@163.com |
| Key Words |
Electroconvulsive therapy; Schizophrenia; Tumor necrosis factor-α; Interleukin-8; Interleukin-18; Treatment response |
| Core Tip |
Compared to healthy controls, acute schizophrenia patients exhibited significantly higher serum tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-8 levels but lower IL-18 levels. After electroconvulsive therapy (ECT), serum IL-8 and IL-18 concentrations increased significantly, while TNF-α remained unchanged. Before ECT, TNF-α positively correlated with Positive and Negative Syndrome Scale general psychopathology scores, while IL-8 negatively correlated with negative symptom scores. After ECT, IL-8 negatively correlated with general psychopathology scores. In ECT responders, post-treatment IL-8 levels positively correlated with improvements in positive symptoms. The study suggests ECT may ameliorate clinical symptoms of acute schizophrenia by modulating inflammatory signaling pathways, particularly IL-8 signaling. |
| Publish Date |
2026-02-28 08:32 |
| Citation |
Xu L, Zhang XB, Luan LS, Yang M, Zhang J, Yang HD, Tang XW. Electroconvulsive therapy alters serum cytokine levels and correlates with symptom improvement in patients with acute schizophrenia. World J Psychiatry 2026; 16(3): 115163 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i3/115163.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i3.115163 |
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