| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Experimental beneficial effect of rosuvastatin on burn wound healing in a rat model
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Alexandra G Marneri, Efstathios T Pavlidis, Kalliopi E Stavrati, Athanasios Kofinas, Christina Mouratidou, Ioannis Gkoutziotis, Serafeim-Chrysovalantis Kotoulas, Christina Marouda, Dimitra Psalla, Konstantinos D Ballas and Theodoros E Pavlidis |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Theodoros E Pavlidis, MD, PhD, Professor Emeritus, The Second Department of Propaedeutic Surgery, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, Konstantinoupoleos 49, Thessaloniki 54642, Greece. pavlidth@auth.gr |
| Key Words |
Experimental skin burns; Statins; Rosuvastatin; Burn wound healing; Skin burn treatment; Inflammation; Anti-inflammatory rosuvastatin action |
| Core Tip |
Overall, the data from this original preclinical study confirm that rosuvastatin does not act unidimensionally but simultaneously influences the inflammatory, angiogenic, and reparative phases of burn wound healing. These findings are consistent with data from other statins and expand our understanding of the mechanisms of action of rosuvastatin, highlighting it as a promising therapeutic agent for treating skin burn wounds. Its superiority is attributed to its unique effect profile. The administration of rosuvastatin was safe in this experimental model, with no observed adverse effects. However, further preclinical and clinical studies to assess its safety and efficacy are warranted. |
| Publish Date |
2026-03-15 06:08 |
| Citation |
Marneri AG, Pavlidis ET, Stavrati KE, Kofinas A, Mouratidou C, Gkoutziotis I, Kotoulas SC, Marouda C, Psalla D, Ballas KD, Pavlidis TE. Experimental beneficial effect of rosuvastatin on burn wound healing in a rat model. World J Exp Med 2026; 16(1): 115208 |
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i1/115208.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v16.i1.115208 |
