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3/25/2026 8:51:32 AM | Browse: 17 | Download: 18
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Received |
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2025-10-17 11:47 |
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Peer-Review Started |
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2025-10-17 11:47 |
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First Decision by Editorial Office Director |
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2025-10-29 08:30 |
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Return for Revision |
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2025-10-29 08:30 |
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Revised |
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2025-11-23 04:31 |
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Publication Fee Transferred |
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2025-11-28 03:16 |
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Second Decision by Editor |
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2026-01-19 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-26 11:49 |
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Articles in Press |
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2026-01-26 11:49 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-18 06:43 |
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Publish the Manuscript Online |
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2026-03-25 08:45 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
An-Ran Wang, Yu-Yang Zhang, Yi-Jun Liu, Li-Nan Ren, Qi-Hui Yan, Kai-Fang Wang and Yan Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Basic Research Program of Shanxi Province |
20210302123241 |
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| Corresponding Author |
Yan Wang, Department of Endocrinology, First Hospital of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan 030001, Shanxi Province, China. wysdyy@126.com |
| Key Words |
Adipose-derived mesenchymal stem cells; Exosomes; Type 2 diabetes mellitus; Insulin sensitivity; Islet function |
| Core Tip |
Researchers have developed a promising new approach to treat type 2 diabetes using exosomes (Exos) derived from adipose-derived mesenchymal stem cells loaded with globular adiponectin (gAd) - referred to as gAd-Exo. The combination of gAd and Exo produced a significant synergistic effect. In a diabetic rat model, gAd-Exo significantly lowered blood glucose, reduced pancreatic islet cell death, and improved insulin sensitivity. It also helped restore the structure and function of pancreatic islets. Mechanistically, gAd-Exo activated key metabolic pathway - AMP-activated protein kinase/acetyl-CoA carboxylase - which are crucial for energy metabolism and cell survival. This study highlights the potential of Exo-mediated delivery to enhance the efficacy of therapeutic molecules like gAd, offering a targeted and sustained treatment strategy for type 2 diabetes. |
| Publish Date |
2026-03-25 08:45 |
| Citation |
Wang AR, Zhang YY, Liu YJ, Ren LN, Yan QH, Wang KF, Wang Y. Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes. World J Stem Cells 2026; 18(3): 115363 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i3/115363.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i3.115363 |
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