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2/11/2026 8:38:22 AM | Browse: 16 | Download: 43
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Received |
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2025-10-16 12:54 |
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Peer-Review Started |
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2025-10-16 12:54 |
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First Decision by Editorial Office Director |
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2025-11-26 09:30 |
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Return for Revision |
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2025-11-26 09:30 |
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Revised |
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2025-11-30 10:51 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-07 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-07 08:48 |
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Articles in Press |
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2026-01-07 08:48 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 00:31 |
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Publish the Manuscript Online |
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2026-02-11 07:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vasily Isakov and Alexei Goncharov |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science and Higher Education of the Russian Federation |
No. FGMF-2025-0003 |
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| Corresponding Author |
Vasily Isakov, AGAF, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, 21 Kashirskoe Shosse, Moscow 115446, Russia. vasily.isakov@gmail.com |
| Key Words |
Primary biliary cholangitis; Vibration-controlled transient elastography; Liver stiffness measurement; Prognostic value; Liver fibrosis staging |
| Core Tip |
Transient elastography is transforming the fibrosis evaluation in primary biliary cholangitis (PBC). The dual cut-offs proposed by Chen et al (≤ 10 kPa and > 14.5 kPa) achieved excellent diagnostic accuracy and could eliminate the need for biopsy in most patients. However, interpretation requires attention to confounders such as cholestasiss, inflammation, and overlap syndromes. Standardized protocols, cross-modality validation, and integration with clinical scores will define the next frontier of precision staging for PBC. |
| Publish Date |
2026-02-11 07:19 |
| Citation |
Isakov V, Goncharov A. Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis. World J Gastroenterol 2026; 32(8): 115416 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i8/115416.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i8.115416 |
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