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2/26/2026 10:27:12 AM | Browse: 120 | Download: 130
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Received |
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2025-10-16 12:59 |
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Peer-Review Started |
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2025-10-16 13:00 |
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First Decision by Editorial Office Director |
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2025-11-05 05:59 |
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Return for Revision |
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2025-11-05 05:59 |
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Revised |
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2025-11-18 20:52 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-17 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-17 11:55 |
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Articles in Press |
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2025-12-17 11:55 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-05 03:23 |
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Publish the Manuscript Online |
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2026-02-26 10:19 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Minireviews |
| Article Title |
Somatostatin and its analogs in the management of postoperative pancreatic fistulas: A comprehensive review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lydia Lazaridou, Alexandra Dimaki, Kalliopi Vakalou, Vasilios Zervas, Panagiotis Papadopoulos, Konstantinos E Koumarelas and Grigorios Christodoulidis |
| Funding Agency and Grant Number |
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| Corresponding Author |
Grigorios Christodoulidis, MD, PhD, Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa 41110, Thessalia, Greece. gregsurg@yahoo.gr |
| Key Words |
Postoperative pancreatic fistula; Pancreatic surgery; Pancreaticoduodenectomy; Distal pancreatectomy; Somatostatin; Somatostatin analogues; Octreotide; Lanreotide; Pasireotide; Prophylaxis |
| Core Tip |
Postoperative pancreatic fistula (POPF) remains a major challenge in pancreatic surgery. Somatostatin and its analogs reduce exocrine secretion and have been widely evaluated for POPF prevention and management. Evidence from recent meta-analyses and randomized trials suggests that while these agents significantly lower POPF incidence, their effect on mortality is minimal. Current research focuses on patient risk stratification and long-acting depot formulations, such as preoperative lanreotide, to enhance compliance and cost-effectiveness. A tailored, risk-adjusted prophylaxis strategy may represent the future standard of care. |
| Publish Date |
2026-02-26 10:19 |
| Citation |
Lazaridou L, Dimaki A, Vakalou K, Zervas V, Papadopoulos P, Koumarelas KE, Christodoulidis G. Somatostatin and its analogs in the management of postoperative pancreatic fistulas: A comprehensive review. World J Gastrointest Surg 2026; 18(2): 115417 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i2/115417.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i2.115417 |
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