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3/12/2026 12:42:47 PM | Browse: 137 | Download: 197
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Received |
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2025-10-21 02:16 |
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Peer-Review Started |
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2025-10-21 02:16 |
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First Decision by Editorial Office Director |
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2025-11-10 06:21 |
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2025-11-10 06:21 |
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Revised |
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2025-11-18 15:32 |
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Publication Fee Transferred |
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2025-11-20 08:04 |
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Second Decision by Editor |
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2025-12-30 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-30 10:12 |
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Articles in Press |
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2025-12-30 10:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-06 08:22 |
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Publish the Manuscript Online |
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2026-03-12 12:25 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Yiqi Wenyang Jiedu prescription promotes disulfidptosis of gastric cancer by reversing senescent cancer-associated fibroblasts
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Yu Kuang, Xiao-Yan Qin, Xin-Miao Wang, Xiao-Tong Song, Xiao-Yu Zhu and Jie Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82305347 and 82505704 |
| Postdoctoral Fellowship Program of CPSF Under |
GZC20233128 |
| Basic Research Operating Expenses Special Fund of Central Public Welfare Research Institutes |
ZZ16-XRZ-037 |
| China Academy of Chinese Medical Sciences Basic Scientific Research Business Fund Outstanding Young Scientific and Technological Talents Training Project |
ZZ17-YQ-009 |
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| Corresponding Author |
Jie Li, Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange Street, Xicheng District, Beijing 100053, China. qfm2020jieli@yeah.net |
| Key Words |
Gastric cancer; Cancer-associated fibroblasts; Yiqi Wenyang Jiedu prescription; Disulfidptosis; Traditional Chinese medicine |
| Core Tip |
This study demonstrates that Yiqi Wenyang Jiedu prescription (YWJP) promotes disulfidptosis in gastric cancer MKN45 cells. The mechanism involves YWJP reversing the senescence of cancer-associated fibroblasts (established by transforming growth factor-β1/H₂O₂), thereby reducing the secretion of HAase. The decrease in HAase leads to the downregulation of GLUT1 and key disulfidptosis-related proteins (CYFIP1, Rac1, ARP2, ARP3). This process increases intracellular disulfide bond levels and cell death, confirming that YWJP induces disulfidptosis via the HAase/GLUT1 pathway. |
| Publish Date |
2026-03-12 12:25 |
| Citation |
Kuang ZY, Qin XY, Wang XM, Song XT, Zhu XY, Li J. Yiqi Wenyang Jiedu prescription promotes disulfidptosis of gastric cancer by reversing senescent cancer-associated fibroblasts. World J Gastrointest Oncol 2026; 18(3): 115505 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i3/115505.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i3.115505 |
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