| ISSN |
2220-315x (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Natalia González Umpiérrez, Estefania Sicco, Felipe Silveira, Aurita Veronica Beovide and Ronell Bologna-Molina |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Ronell Bologna-Molina, PhD, Professor, Department of Diagnostics in Oral Pathology and Oral Medicine, Faculty of Dentistry, University of the Republic, Las Heras 1925, Montevideo 11600, Uruguay. ronellbologna@hotmail.com |
| Key Words |
Caveolin-1; MOC-31; Connexin-43; Ki-67; Odontogenic tumors |
| Core Tip |
This study compared the immunohistochemical expression of caveolin-1, MOC-31, connexin-43 (Cx-43), and Ki-67 in ameloblastic fibroma (AF), ameloblastic fibrodentinoma (AFD), ameloblastic fibro-odontoma (AFO), and odontoma (O). AF, AFD, and AFO showed similar epithelial and mesenchymal profiles, with lower expression in O. Significant differences in MOC-31 and Cx-43 between AF/AFO and O suggest that AFD and AFO may represent variants of AF rather than developing odontomas. These findings contribute to understanding the biological behavior and classification of mixed odontogenic tumors. |
| Publish Date |
2026-03-15 06:14 |
| Citation |
Umpiérrez NG, Sicco E, Silveira F, Beovide AV, Bologna-Molina R. Differences of immunohistochemical profiling of MOC-31, caveolin-1, connexin-43, Ki-67 in ameloblastic fibroma, ameloblastic fibrodentinoma, ameloblastic fibro-odontoma, and odontomas. World J Exp Med 2026; 16(1): 115508 |
| URL |
https://www.wjgnet.com/2220-315x/full/v16/i1/115508.htm |
| DOI |
https://dx.doi.org/10.5493/wjem.v16.i1.115508 |
