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1/5/2026 6:44:23 AM | Browse: 24 | Download: 12
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Received |
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2025-10-20 01:26 |
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Peer-Review Started |
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2025-10-20 01:26 |
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First Decision by Editorial Office Director |
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2025-10-29 09:34 |
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Return for Revision |
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2025-10-29 09:34 |
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Revised |
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2025-11-08 03:50 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-18 01:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-18 09:38 |
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Articles in Press |
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2025-11-18 09:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-25 11:35 |
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Publish the Manuscript Online |
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2026-01-05 03:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Herbal medicine beyond probiotics: Yiyi Fuzi Baijiang powder and the holistic regulation of gut microbiota in ulcerative colitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hua-Jun Zhang, Shui-Quan Jin, Ding-Jun Cai and Zhi-Peng He |
| Funding Agency and Grant Number |
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| Corresponding Author |
Zhi-Peng He, MD, Professor, Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), No. 54 Youdian Road, Shangcheng District, Hangzhou 310000, Zhejiang Province, China. hezhipeng0901@163.com |
| Key Words |
Yiyi Fuzi Baijiang powder; Ulcerative colitis; Gut microbiota; Network pharmacology; Short-chain fatty acids; Multi-omics integration; Nuclear factor kappa-B signaling pathway; Synergistic mechanism |
| Core Tip |
Yiyi Fuzi Baijiang powder (YFB) represents a paradigm shift in treating ulcerative colitis. Unlike conventional probiotics, YFB restores gut ecosystem equilibrium via a dual pathway: Its compounds directly mitigate inflammation while normalizing the intestinal oxygen landscape. This rectifies the hypoxic environment, explaining the paradoxical reduction of overgrown anaerobes like Bifidobacterium as a sign of ecosystem recovery, not a drawback. Integrating multi-omics techniques reveals YFB’s holistic, synergistic mechanism. Future work should employ molecular dynamics and metabolite assays to further decipher this sophisticated system-rebalancing approach. |
| Publish Date |
2026-01-05 03:46 |
| Citation |
Zhang HJ, Jin SQ, Cai DJ, He ZP. Herbal medicine beyond probiotics: Yiyi Fuzi Baijiang powder and the holistic regulation of gut microbiota in ulcerative colitis. World J Gastroenterol 2026; 32(1): 115543 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i1/115543.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i1.115543 |
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