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4/14/2026 9:00:43 AM | Browse: 18 | Download: 36
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Received |
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2025-10-28 06:32 |
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Peer-Review Started |
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2025-10-29 00:27 |
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2025-11-14 06:22 |
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2025-11-14 06:22 |
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2025-12-17 02:03 |
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2025-12-19 02:07 |
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Second Decision by Editor |
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2026-03-05 02:45 |
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Final Decision by Editorial Office Director |
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2026-03-05 04:44 |
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Articles in Press |
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2026-03-05 04:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-30 05:30 |
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Publish the Manuscript Online |
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2026-04-14 08:58 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Basic Study |
| Article Title |
Type 2 diabetes mellitus may be associated with a novel mitochondrial tRNAThr/tRNAPro mutation: A basic study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Liang Xu, Meng-Ting Liu, Xiu-Mei He, Shun-Rong Zhang, Dao-Jun Yu and Yu Ding |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Project of Natural Science Foundation of Zhejiang Province |
No. LZ22H190002 |
| Hangzhou Joint Fund of the Zhejiang Provincial Natural Science Foundation of China |
No. LHZY24H020002 |
| Key Project of Hangzhou Bureau of Science and Technology |
No. 202204A01 |
| Zhejiang Provincial Medicine and Health Science Foundation |
No. WKJ-ZJ-2514 |
| Construction Fund of Key Medical Disciplines of Hangzhou, Laboratory Diagnostics |
No. 2025HZZD01 |
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| Corresponding Author |
Yu Ding, Associate Professor, MD, Department of Clinical Laboratory, Hangzhou First People’s Hospital, No. 261 Huansha Road, Hangzhou 310006, Zhejiang Province, China. dingyu_zj@126.com |
| Key Words |
Type 2 diabetes mellitus; Mitochondrial tRNAThr/tRNAPro; m.C15954T mutation; Mitochondrial dysfunctions; Adenosine triphosphate |
| Core Tip |
This study reports a Han Chinese pedigree with maternally inherited type 2 diabetes mellitus. We identified a novel mitochondrial (mt) C15954T mutation located in the intergenic spacer between the mt-tRNAThr and mt-tRNAPro genes. Phylogenetic analysis revealed that the nucleotide at position 15954 is highly conserved across species, suggesting a potential role in the 3’ end processing of both tRNAThr and tRNAPro. Using trans-mitochondrial cybrid models, we demonstrated that the m.C15954T mutation leads to impaired mt-transfer RNA metabolism and significant mt dysfunction. These findings indicate that the m.C15954T mutation may contribute to the pathogenesis of diabetes in this pedigree. |
| Publish Date |
2026-04-14 08:58 |
| Citation |
Xu L, Liu MT, He XM, Zhang SR, Yu DJ, Ding Y. Type 2 diabetes mellitus may be associated with a novel mitochondrial tRNAThr/tRNAPro mutation: A basic study. World J Diabetes 2026; 17(4): 115842 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i4/115842.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i4.115842 |
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