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4/17/2026 7:41:14 AM | Browse: 134 | Download: 293
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Received |
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2025-11-05 06:07 |
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Peer-Review Started |
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2025-11-05 06:07 |
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First Decision by Editorial Office Director |
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2025-12-02 10:13 |
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Return for Revision |
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2025-12-02 10:13 |
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Revised |
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2025-12-19 06:19 |
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Publication Fee Transferred |
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2025-12-26 11:50 |
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Second Decision by Editor |
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2026-02-09 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-09 07:07 |
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Articles in Press |
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2026-02-09 07:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-08 00:24 |
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Publish the Manuscript Online |
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2026-04-17 07:16 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Modulation of the gut-liver axis by oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Fang Xiong, Ying He, Na Jiang, Yi-Hui Liu, Gao-Feng Chen, Chang-Qing Zhao, Shu-Yan Zhang, Yi-Jun Wu and Hong Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82074100 |
| Hangzhou Science and Technology Bureau |
No. 20201203B175 |
| Scientific Research Fund for TCM in Zhejiang Province |
No. 2023ZL551 |
| Scientific Research Fund for TCM in Zhejiang Province |
No. 2023ZL558 |
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| Corresponding Author |
Hong Xu, Chief Physician, Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, No. 208 Huancheng Dong Road, Hangzhou 310003, Zhejiang Province, China. hongxuhzrc@aliyun.com |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Alcoholic liver disease; Metabolic dysfunction-associated steatohepatitis; Insulin resistance; Oxidative stress |
| Core Tip |
Oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease, primarily through modulation of the gut microbiome (increasing Lactobacillus, reducing Firmicutes/Bacteroidetes ratio) and the hepatic metabolome (increasing luteolin, decreasing adrenic acid). Fecal microbiota transplantation from oxymatrine donors recapitulated this protection, establishing a causal gut-liver axis for this natural alkaloid and offering a microbiota-guided therapeutic perspective. |
| Publish Date |
2026-04-17 07:16 |
| Citation |
Xiong JF, He Y, Jiang N, Liu YH, Chen GF, Zhao CQ, Zhang SY, Wu YJ, Xu H. Modulation of the gut-liver axis by oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(16): 116187
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i16/116187.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i16.116187 |
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