Publication Name	World Journal of Clinical Cases
Manuscript ID	11628
Country	United States

Received	2014-05-28 21:20
Peer-Review Started	2014-05-28 22:27
To Make the First Decision	2014-08-14 14:41
Return for Revision	2014-08-18 08:28
Revised	2014-08-23 00:30
Second Decision	2014-10-16 15:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-16 15:58
Articles in Press	2014-10-16 15:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-10 19:08
Publish the Manuscript Online	2014-12-18 14:44

ISSN	2307-8960 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Engineering, Biomedical
Manuscript Type	Review
Article Title	Drug-targeting methodologies with applications: A review
Manuscript Source	Invited Manuscript
All Author List	Clement Kleinstreuer, Yu Feng and Emily Childress
Funding Agency and Grant Number	Funding Agency Grant Number National Science Foundation NSF-CBET 1232988 ANSYS Inc. (Canonsburg, PA)
Corresponding Author	Clement Kleinstreuer, PhD, Professor, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, United States. ck@ncsu.edu
Key Words	Targeted drug delivery; Pulmonary system; Vascular system; Types of drugs and delivery devices; Computational analysis and experimental evidence; Future work
Core Tip	Targeted drug delivery to diseased areas or solid tumors has the great potential to significantly improve treatment efficacy, minimize side-effects, and reduce health-care cost. The major problem addressed is how to deliver efficiently the drug-particles from the entry/infusion point to the target site. Past and present developments in drug formulation and associated drug-delivery devices are discussed. Examples of optimal drug delivery to pulmonary target sites as well as targeting solid tumors in the vascular system are reviewed.
Publish Date	2014-12-18 14:44
Citation	Kleinstreuer C, Feng Y, Childress E. Drug-targeting methodologies with applications: A review. World J Clin Cases 2014; 2(12): 742-756
URL	http://www.wjgnet.com/2307-8960/full/v2/i12/742.htm
DOI	http://dx.doi.org/10.12998/wjcc.v2.i12.742

Full Article (PDF)	WJCC-2-742.pdf
Full Article (Word)	WJCC-2-742.doc
Manuscript File	11628-Review.docx
Answering Reviewers	11628-Answering reviewers.pdf
Copyright License Agreement	11628-Copyright assignment.PDF
Peer-review Report	11628-Peer review(s).pdf
Scientific Misconduct Check	11628-CrossCheck.jpg
Scientific Editor Work List	11628-Scientific editor work list.pdf