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12/18/2014 4:22:00 PM | Browse: 699 | Download: 1785
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Received |
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2014-05-28 21:20 |
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Peer-Review Started |
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2014-05-28 22:27 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-08-18 08:28 |
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Revised |
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2014-08-23 00:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-10-16 15:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-10-16 15:58 |
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Articles in Press |
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2014-10-16 15:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-12-10 19:08 |
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Publish the Manuscript Online |
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2014-12-18 14:44 |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Review |
| Article Title |
Drug-targeting methodologies with applications: A review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Clement Kleinstreuer, Yu Feng and Emily Childress |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Foundation |
NSF-CBET 1232988 |
| ANSYS Inc. (Canonsburg, PA) |
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| Corresponding Author |
Clement Kleinstreuer, PhD, Professor, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695,
United States. ck@ncsu.edu
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| Key Words |
Targeted drug delivery; Pulmonary system; Vascular system; Types of drugs and delivery devices; Computational analysis and experimental evidence; Future work |
| Core Tip |
Targeted drug delivery to diseased areas or solid tumors has the great potential to significantly improve treatment efficacy, minimize side-effects, and reduce health-care cost. The major problem addressed is how to deliver efficiently the drug-particles from the entry/infusion point to the target site. Past and present developments in drug formulation and associated drug-delivery devices are discussed. Examples of optimal drug delivery to pulmonary target sites as well as targeting solid tumors in the vascular system are reviewed.
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| Publish Date |
2014-12-18 14:44 |
| Citation |
Kleinstreuer C, Feng Y, Childress E. Drug-targeting methodologies with applications: A review. World J Clin Cases 2014; 2(12): 742-756 |
| URL |
http://www.wjgnet.com/2307-8960/full/v2/i12/742.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v2.i12.742 |
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