| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Qiweizhigan granule ameliorates metabolic dysfunction-associated steatohepatitis by modulating the galectin 3/tumor necrosis factor receptor-associated factor 6-mediated ferroptosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Nuo Yang, Yun-Hong Sun, Ming-Zhe Zhu, Yi-Rong Wang, Meng Li, Kai Wang, Jing Ma, Li Zhang, Dan Hu, Wen-Jun Zhou, Guang Ji and Yan-Qi Dang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82530124 |
| Digestive Diseases Committee of the Chinese Association of Traditional Chinese Medicine-The Youth Empowerment Program |
No. 202557-006 |
| State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine |
No. LSLSKL20240127 |
|
| Corresponding Author |
Yan-Qi Dang, Institute of Digestive Diseases, China-Canada Center of Research for Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Fenglin Road Subdistrict, Shanghai 200032, China. yq_dang@shutcm.edu.cn |
| Key Words |
Qiweizhigan granule; Metabolic dysfunction-associated steatohepatitis; Galectin 3; Tumor necrosis factor receptor-associated factor 6; Ferroptosis |
| Core Tip |
This study reveals that galectin 3 plays a critical role in the progression of metabolic dysfunction-associated steatohepatitis by regulating ferroptosis through the tumor necrosis factor receptor-associated factor 6/glutathione peroxidase 4 axis. The traditional Chinese medicine Qiweizhigan granule significantly alleviates the progression of metabolic dysfunction-associated steatohepatitis by targeting the galectin 3/tumor necrosis factor receptor-associated factor 6/glutathione peroxidase 4 axis. |
| Publish Date |
2026-04-24 05:43 |
| Citation |
Yang YN, Sun YH, Zhu MZ, Wang YR, Li M, Wang K, Ma J, Zhang L, Hu D, Zhou WJ, Ji G, Dang YQ. Qiweizhigan granule ameliorates metabolic dysfunction-associated steatohepatitis by modulating the galectin 3/tumor necrosis factor receptor-associated factor 6-mediated ferroptosis. World J Gastroenterol 2026; 32(17): 116386 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i17/116386.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i17.116386 |
